{
  "abstract": "This study investigated the skin-whitening and anti-photoaging activities of a culture supernatant obtained by cultivating Limosilactobacillus reuteri DS0333 in chemically defined medium (CDM) supplemented with unripe Rubus occidentalis L. extract (UROE). DS0333 was cultured in UROE-supplemented medium, and the resulting DS0333/(CDM+UROE) group was evaluated alongside all control and comparison groups. The DS0333/(CDM+UROE) culture supernatant showed enhanced DPPH and ABTS radical scavenging activities compared with all other experimental groups. In α-MSH-stimulated B16F10 cells, the culture supernatant reduced melanin content and intracellular tyrosinase activity and downregulated MITF, TRP-1, and TRP-2 expression. In UVB-irradiated human dermal fibroblasts, the culture supernatant increased type I procollagen production, reduced MMP-1 levels, and suppressed MMP-1/MMP-3 expression through attenuation of the MAPK/AP-1 signaling pathway. These results suggest that culturing DS0333 in UROE-supplemented medium enhances skin-whitening and anti-photoaging activities, potentially through cultivation-associated modification of extracellular metabolites in the culture matrix. Therefore, the DS0333/(CDM+UROE) culture supernatant may serve as a promising multifunctional cosmetic ingredient for skin applications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biocosmetics, Dongshin University, 185, Gunjae-ro, Naju 58245, Jeonnam, Republic of Korea.",
    "RAPPOL, 30, Okcheon-gil, Suncheon 57941, Jeonnam, Republic of Korea.",
    "Department of Petrochemical Process, Hanyeong University, 18-43, Janggunsan-gil, Yeosu 59720, Jeonnam, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nu Ri Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Seo Yeon Shin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jae Hee Byun"
    },
    {
      "affs": [
        0
      ],
      "name": "Seon Ju Kim"
    },
    {
      "affs": [
        1
      ],
      "name": "Hye Young Kim"
    },
    {
      "affs": [
        2
      ],
      "name": "Won Seok Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Kyung Mok Park"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a2esdpv8wfzs1.bib",
  "cited_by": 0,
  "doi": "10.4014/jmb.2606.06047",
  "fulltext_url": "https://europepmc.org/articles/PMC13686808",
  "id": "a2esdpv8wfzs1",
  "issns": [
    "1017-7825",
    "1738-8872"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897972",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1106|Probiotics and Fermented Foods"
    ]
  ],
  "openalex": "W7223014774",
  "pdf_url": "https://europepmc.org/articles/PMC13686808?pdf=render",
  "pmcid": "PMC13686808",
  "pmid": "42897972",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a2esdpv8wfzs1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42897972",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897972"
    }
  ],
  "subjects": [],
  "title": "Skin-Whitening and Anti-Photoaging Activities of Limosilactobacillus reuteri DS0333 Culture Supernatant Produced in Unripe Rubus occidentalis L. Extract-Supplemented Medium.",
  "title_text": "Skin-Whitening and Anti-Photoaging Activities of Limosilactobacillus reuteri DS0333 Culture Supernatant Produced in Unripe Rubus occidentalis L. Extract-Supplemented Medium.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/a2esdpv8wfzs1",
  "venue": "Journal of microbiology and biotechnology",
  "versions": []
}