{
  "abstract": "Background: This systematic review and meta-analysis evaluated the global prevalence of vancomycin-resistant enterococci among patients with hematological malignancies, particularly vulnerable immunocompromised populations including leukemia, lymphoma, neutropenia, and hematopoietic stem cell transplantation patients.\n\nMethods: A systematic literature search of PubMed, Scopus, and Google Scholar was conducted for studies published up to March 2026. Eligible observational studies reporting the prevalence of VRE in patients with hematological malignancies were included. Study quality was assessed using the Joanna Briggs Institute checklist and PRISMA 2020 guidelines. Random-effects meta-analysis using logit-transformed proportions was performed in OpenMetaAnalyst and Comprehensive Meta-Analysis software. Heterogeneity was assessed using Cochran’s Q and I ² statistics. Subgroup analysis, sensitivity analysis, publication bias assessment, and meta-regression were conducted to identify potential sources of heterogeneity.\n\nResults: A total of 120 studies involving patients with hematological malignancies were included. The pooled prevalence of VRE was 18.4% (95% CI: 15.5–21.6%), with substantial heterogeneity ( I ² = 97.56%, p < 0.001). Publication bias was detected by funnel plot asymmetry, Egger’s regression ( p = 0.0224), and Begg’s test ( p = 0.0226). Subgroup analysis demonstrated considerable geographic variation, with the highest prevalence observed in South America (25.5%) and Australia (22.8%). HSCT patients showed the highest pooled prevalence (97.1%), followed by neutropenic patients (91.2%) and acute myeloid leukemia patients (68.3%). Meta-regression identified continent as a significant contributor to heterogeneity ( Q = 11.68, p = 0.0395), whereas detection method and sample type were not significant moderators.\n\nConclusion: VRE represents a substantial global burden among patients with hematological malignancies, particularly in HSCT and neutropenic populations.\n\nSystematic review registration: 10.17605/OSF.IO/2VH9D .",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, College of Medicine, Qassim University"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fatimah Suliman Mohammad Aljebaly"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a31ejmttb9tps.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1945305",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716793/?tool=EBI",
  "id": "a31ejmttb9tps",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1945305/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7221869848",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716793/pdf/?tool=EBI",
  "pmcid": "PMC13716793",
  "pmid": "42959153",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a31ejmttb9tps.ris",
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      "url": "https://doi.org/10.3389/fpubh.2026.1945305"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2296-2565",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Global prevalence of vancomycin-resistant Enterococcus in patients with haematological malignancies: a systematic review and meta-analysis",
  "title_text": "Global prevalence of vancomycin-resistant Enterococcus in patients with haematological malignancies: a systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:14Z",
  "url": "https://research.draconitic.com/paper/a31ejmttb9tps",
  "venue": "Frontiers in Public Health",
  "versions": []
}