{
  "abstract": "Objectives\n\nSex-specific differences in sarcopenia-related prognosis after cardiac surgery are unclear. We aimed to investigate the association between preoperative computed tomography-defined sarcopenia and postoperative complications in older patients undergoing elective cardiac surgeries, focusing on sex-specific differences.Methods\n\nThis retrospective observational study included 133 patients aged 65 years or more who underwent elective open surgeries. Sarcopenia was assessed using the psoas muscle area index derived from preoperative computed tomography scans and defined using sex-specific cutoff values. The primary outcome was postoperative complication.Results\n\nForty-nine patients (36.8%) had sarcopenia. Although the incidence of complications was higher in this group, the difference was not statistically significant between the groups. Multivariate logistic regression analysis excluding patients with preexisting atrial fibrillation revealed that sarcopenia was independently associated with a higher risk of postoperative complications (odds ratio, 3.73, 95% CI, 1.49-9.84, P = .006). The male patients with sarcopenia showed a higher incidence of complications versus those without (56.8% vs 33.9%, P = .046), whereas no association was observed in the female patients. Sex-stratified analyses confirmed the independent prognostic value of sarcopenia in male patients only (odds ratio, 2.52, 95% CI, 1.08-6.01, P = .033).Conclusions\n\nPreoperative computed tomography-defined sarcopenia was independently associated with postoperative complications in older male patients undergoing elective cardiac surgeries, but not in female patients. These findings suggest that the prognostic significance of sarcopenia is sex-specific and highlight the importance of sex-specific risk stratification strategies in older patient populations undergoing cardiac surgeries.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Surgery, Nippon Medical School, Tokyo, Japan.",
    "Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.",
    "Department of Health Policy and Management, Nippon Medical School, Tokyo, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hitomi Ueda"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoshiaki Kubota"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuji Maruyama"
    },
    {
      "affs": [
        2
      ],
      "name": "Takuya Nishino"
    },
    {
      "affs": [
        1
      ],
      "name": "Kuniya Asai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yosuke Ishii"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a346sg3anprm0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjon.2026.101975",
  "fulltext_url": "https://europepmc.org/articles/PMC13711167",
  "id": "a346sg3anprm0",
  "issns": [
    "2666-2736"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948417",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Adult: Perioperative Management"
    ],
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7171448536",
  "pdf_url": "https://europepmc.org/articles/PMC13711167?pdf=render",
  "pmcid": "PMC13711167",
  "pmid": "42948417",
  "published": "2026-07-27",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/a346sg3anprm0.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948417",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948417"
    },
    {
      "first_seen": "2026-10-31T12:21:59Z",
      "native_id": "PMC13711167",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xjon.2026.101975"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Sex-specific impact of computed tomography-defined sarcopenia on postoperative complications following elective cardiac surgery in older patients.",
  "title_text": "Sex-specific impact of computed tomography-defined sarcopenia on postoperative complications following elective cardiac surgery in older patients.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:59Z",
  "url": "https://research.draconitic.com/paper/a346sg3anprm0",
  "venue": "JTCVS open",
  "versions": []
}