{
  "abstract": "Background\n\nThe impact of dominant follicular diameter at hCG trigger on live birth rate (LBR) in modified natural cycle frozen-thawed embryo transfer (mNC-FET) remains unclear. This study aimed to evaluate this relationship and explore whether flexible triggering based on follicle size is acceptable.Methods\n\nA retrospective study included 1669 mNC-FET cycles. The cycles were divided according to the dominant follicle diameter on the hCG day: ≥16 mm (n = 1439) and <16 mm (n = 230). The LBR was compared between the groups, and multivariate logistic regression was performed. A subgroup analysis stratified by maternal age (≥ 35 years) was conducted.Results\n\nOverall, the LBR did not significantly differ between the <16 mm groups (49.0% vs 43.9%, P = 0.152; adjusted OR = 0.878, 95% CI 0.626-1.230). Among advanced-age women (≥35 years), the ≥16 mm group showed a significantly higher LBR (40.2% vs 28.0%, P = 0.048), but multivariate analysis revealed no independent association after adjusting for confounders (aOR = 0.963, 95% CI 0.517-1.791, P = 0.904).Conclusion\n\nDominant follicular diameter on the hCG day was not independently associated with the live birth rate in mNC-FET. The crude difference seen in women aged advanced-age women (≥35 yeaadjustment and should be viewed as hypothesis-generating rather than effect modification. Flexible triggering may be acceptable, while maternal age remains a key clinical consideration in individualizing trigger timing.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing, 210008, People's Republic of China.",
    "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, People's Republic of China.",
    "Center for Molecular Reproductive Medicine, Nanjing University, Nanjing, 210008, People's Republic of China.",
    "State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, 210008, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Chenyang Huang",
      "orcid": "0000-0003-4011-2034"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yue Jiang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jingyu Liu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yingchun Zhu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Hui Zhang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Ruiwei Jiang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Fangfang He"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jun Xing"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3dd2zjd8wak2.bib",
  "cited_by": 0,
  "doi": "10.2147/ijgm.s648290",
  "fulltext_url": "https://europepmc.org/articles/PMC13695968",
  "id": "a3dd2zjd8wak2",
  "issns": [
    "1178-7074"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928808",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Reproductive Biology and Fertility"
    ]
  ],
  "openalex": "W7223084854",
  "pdf_url": "https://europepmc.org/articles/PMC13695968?pdf=render",
  "pmcid": "PMC13695968",
  "pmid": "42928808",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a3dd2zjd8wak2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928808",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928808"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Reproductive Biology and Fertility",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Relationship Between Dominant Follicle Diameter on the hCG Trigger Day and Live Birth After Modified Natural Cycle Frozen Embryo Transfer: A Retrospective Cohort Study.",
  "title_text": "Relationship Between Dominant Follicle Diameter on the hCG Trigger Day and Live Birth After Modified Natural Cycle Frozen Embryo Transfer: A Retrospective Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/a3dd2zjd8wak2",
  "venue": "International journal of general medicine",
  "versions": []
}