{
  "abstract": "Introduction: Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by Echinococcus granulosus, and the T and B cell responses and regulatory mechanisms in CE remain unclear.\n\nMethods: In this study, we analyzed the data of peripheral blood and spleen of mice infected with Echinococcus granulosus(EG) by scRNA +TCR+BCR-seq.\n\nResults: We made the following novel findings: (1) Peripheral blood of Echinococcus granulosus (EG)-infected mice contained a higher proportion of dual TCR(T cell receptor) T cells with higher clonality than uninfected mice; (2) There was a bias in V gene usage between single TCR T and dual TCR T cells, as well as between single BCR(B cell receptor) B cells and dual BCR B cells in EG-infected mice; (3) Dual TCR Tregs, dual TCR effector CD8 T cells, dual BCR Bregs, and dual BCR memory/dividing B cells exhibited relatively high clonal expansion in EG-infected mice; (4) Shared CDR3 sequences and consistently highly expressed mRNA molecules exist between single receptor T/B and dual receptor T/B cells in EG-infected mice. KEGG enrichment analysis revealed that dual BCR B cells are closely related to the expression of factors associated with pathways such as \"Th1/ Th2 differentiation\" and \"antigen processing and presentation\".\n\nDiscussion: These results suggest that dual TCR T and dual BCR B cells may be involved in the specific responses and regulation of EG-infected mice, providing a novel perspective for the adaptive immune response mechanisms and targeted therapy of parasitic infections.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Affiliated Hospital of Zunyi Medical University",
    "Department of Immunology, Zunyi Medical University; Guizhou Provincial Research Center for Applied Molecular Immunology; Guizhou Provincial Graduate Education Innovation Base for Immunology; Guizhou Provincial Key Discipline of Immunology",
    "Central Laboratory, Guizhou Aerospace Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Peng Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Kai Quan"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongxia Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yadong Gong"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinsheng Yao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3dtz06xgedke.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1835604",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710079/",
  "id": "a3dtz06xgedke",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835604/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2734|Parasitic infections in humans and animals"
    ]
  ],
  "openalex": "W7221645818",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1835604/pdf",
  "pmcid": "PMC13710079",
  "pmid": "42947822",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a3dtz06xgedke.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1835604",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835604/full"
    },
    {
      "first_seen": "2026-10-31T12:21:07Z",
      "native_id": "PMC13710079",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1835604"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Preliminary analysis of the proportions and characteristics of dual TCR T cells and dual BCR B cells in echinococcus granulosus-infected mice using scRNA+TCR+BCR-seq",
  "title_text": "Preliminary analysis of the proportions and characteristics of dual TCR T cells and dual BCR B cells in echinococcus granulosus-infected mice using scRNA+TCR+BCR-seq",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:07Z",
  "url": "https://research.draconitic.com/paper/a3dtz06xgedke",
  "venue": "Frontiers in Immunology",
  "versions": []
}