{
  "abstract": "Background: Transcatheter aortic valve implantation (TAVI) with the Acurate Neo has been linked to a significant incidence of paravalvular leakage (PVL), addressed by the Acurate Neo 2 incorporating an active sealing skirt. Recent findings suggest that midframe under‐expansion is associated with worse outcomes.\n\nAims: We investigated the hemodynamic and clinical outcomes after TAVI with Acurate Neo 2 compared to Acurate Neo and assessed the impact of midframe under‐expansion.\n\nMethods: Patients who received Acurate Neo (n = 124) or Acurate Neo 2 (n = 133) between February 2018 and December 2021 (switch to Acurate Neo 2 in November 2020) were included. The primary outcomes were VARC‐3 defined device success and early safety.\n\nResults: Device success was higher with Acurate Neo 2 compared with Acurate Neo (94.7% vs. 86.3%, p = 0.020), as was early safety (87.2% vs. 74.2%, p = 0.008). The rate of mild/moderate PVL was significantly lower in Acurate Neo 2. Kaplan−Meier estimated 1‐year survival (Acurate Neo 2: 87.8% vs. Acurate Neo: 89.0, p = 0.930) and freedom from the combined clinical endpoint death, stroke, myocardial infarction, and heart failure rehospitalization at 1 year (Acurate Neo 2: 81.2% vs. Acurate Neo: 79.3%, p = 0.528) were comparable between groups. A long‐term analysis of these endpoints revealed no difference between groups. Midframe under‐expansion occurred in 13.3% and was associated with lower freedom from the combined clinical endpoint at 1 year, irrespective of prosthesis generation.\n\nConclusion: Acurate Neo 2 demonstrated significant improvements in device success and early safety compared to Acurate Neo. Midframe under‐expansion occurred with both generations and was associated with worse clinical outcomes within the first year.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine and Cardiology Heart Center Dresden, Technische Universität Dresden Dresden Germany",
    "Department of Cardiac Surgery Heart Center Dresden, Technische Universität Dresden Dresden Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lisa Crusius"
    },
    {
      "affs": [
        0
      ],
      "name": "Thaddäus Ast",
      "orcid": "0009-0004-9857-6936"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephan Haussig"
    },
    {
      "affs": [
        0
      ],
      "name": "Jean‐Honoré Steul"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix J. Woitek"
    },
    {
      "affs": [
        0
      ],
      "name": "Peter Sick"
    },
    {
      "affs": [
        1
      ],
      "name": "Tomas Madej",
      "orcid": "0009-0004-4563-1962"
    },
    {
      "affs": [
        1
      ],
      "name": "Utz Kappert",
      "orcid": "0000-0001-8202-7570"
    },
    {
      "affs": [
        0
      ],
      "name": "Axel Linke"
    },
    {
      "affs": [
        0
      ],
      "name": "Norman Mangner",
      "orcid": "0000-0003-0793-7923"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3kndtp9zdyra.bib",
  "cited_by": 0,
  "doi": "10.1002/ccd.70839",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725193/",
  "id": "a3kndtp9zdyra",
  "issns": [
    "1522-1946",
    "1522-726X"
  ],
  "landing_url": "https://doi.org/10.1002/ccd.70839",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article ‐ Clinical Science"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7205000286",
  "pdf_url": null,
  "pmcid": "PMC13725193",
  "pmid": "42681886",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a3kndtp9zdyra.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:38Z",
      "native_id": "PMC13725193",
      "source": "pmc",
      "url": "https://doi.org/10.1002/ccd.70839"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Comparison Between the Acurate Neo and the Acurate Neo 2 Transcatheter Heart Valve System: Impact of Midframe Under‐Expansion",
  "title_text": "Comparison Between the Acurate Neo and the Acurate Neo 2 Transcatheter Heart Valve System: Impact of Midframe Under‐Expansion",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:31Z",
  "url": "https://research.draconitic.com/paper/a3kndtp9zdyra",
  "venue": "Catheterization and Cardiovascular Interventions",
  "versions": []
}