{
  "abstract": ". Here we identified a relationship between the morphologies, gene expression and activity of noradrenergic neurons in locus coeruleus in mice. Axonal projections of individual neurons were extensive but largely confined to subsets of brain regions. Axonal projections and graded gene expression correlated with locations of cell bodies in locus coeruleus. In a behavioural task requiring continuous learning from actions, dorsal locus coeruleus neurons projecting to isocortex were activated when mice switched choices and by reward-prediction-error signals that drive learning. Background activity of neurons in ventral locus coeruleus was higher when mice ignored stimuli indicating potential reward availability. These observations reveal a topographically organized structure and function of a neurotransmitter system and show that it contains learning signals for flexible behaviour.",
  "abstract_shown": true,
  "affiliations": [
    "Allen Institute, Neural Dynamics, Seattle, WA, USA",
    "Allen Institute, Brain Science, Seattle, WA, USA",
    "Allen Institute, Neural Dynamics, Seattle, WA, USA. yoh.isogai@alleninstitute.org",
    "Allen Institute, Neural Dynamics, Seattle, WA, USA. jayaramc@alleninstitute.org",
    "Allen Institute, Neural Dynamics, Seattle, WA, USA. jeremiah.cohen@alleninstitute.org"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 55,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhixiao Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Polina Kosillo",
      "orcid": "0000-0002-1944-9460"
    },
    {
      "affs": [
        0
      ],
      "name": "Kanghoon Jung",
      "orcid": "0000-0002-5381-5161"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuonan Chen"
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    {
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        0
      ],
      "name": "Mathew T. Summers",
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    {
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        0
      ],
      "name": "Alex T. Piet",
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    {
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      ],
      "name": "Han Hou",
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      "name": "Kenta M. Hagihara",
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      "name": "Drew Friedmann",
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      "name": "Matthew I. Becker",
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      "name": "Xinxin Yin"
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      "name": "Peter Grotz"
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      "name": "Ella Hilton-VanOsdall",
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      "name": "Margaret Lee",
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      "name": "Samantha L. Black",
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      "name": "Naveen D. Ouellette",
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      "name": "Holly Myers",
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      "name": "Judith Baka",
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      "name": "Camilo Laiton-Bonadiez",
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      "name": "Kaelin Wulf",
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      "name": "Alessio Paolo Buccino",
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      "name": "Cameron Arshadi",
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      "name": "Di Wang"
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      "name": "Sharmishtaa Seshamani",
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      "name": "Sonya Vasquez"
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      "name": "Carolyn M. Eng",
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      "name": "Douglas R. Ollerenshaw",
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      "name": "Windy Ho",
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      "name": "Matthew Jungert",
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      "name": "Atlas Jordan",
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      "name": "Elliot J Phillips",
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      "name": "Anish Bhaswanth Chakka",
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      "name": "Kamiliam Nasirova",
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      "name": "Krista Blake",
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      "name": "Megan Koch",
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      "name": "María Camila Vergara",
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      "name": "Kimberly A. Smith",
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      "name": "Tim Jarsky",
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      "name": "Nicholas A. Lusk",
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      "name": "Mara C.P. Rue",
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      "name": "Xiaoyin Chen",
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      "name": "Joshua H. Siegle",
      "orcid": "0000-0002-7736-4844"
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      "name": "Jayaram V. Chandrashekar",
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  "bibtex": "https://research.draconitic.com/paper/a3m9dvfxd5dth.bib",
  "cited_by": 5,
  "doi": "10.1038/s41586-026-11026-0",
  "fulltext_url": null,
  "id": "a3m9dvfxd5dth",
  "issns": [
    "0028-0836",
    "1476-4687"
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  "landing_url": "https://doi.org/10.1038/s41586-026-11026-0",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2804|Neurotransmitter Receptor Influence on Behavior"
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  "openalex": "W7213401690",
  "pdf_url": null,
  "pmcid": "PMC13082035",
  "pmid": "41993290",
  "published": "2026-09-16",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/a3m9dvfxd5dth.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
      "native_id": "W7213401690",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41586-026-11026-0"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neurotransmitter Receptor Influence on Behavior",
      "subfield": "neuroscience"
    }
  ],
  "title": "Topographic structure and function of locus coeruleus noradrenaline neurons",
  "title_text": "Topographic structure and function of locus coeruleus noradrenaline neurons",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T13:21:11Z",
  "url": "https://research.draconitic.com/paper/a3m9dvfxd5dth",
  "venue": "Nature",
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}