{
  "abstract": "Four previously undescribed guaiane-type sesquiterpenoid glycosides, crodonsides A–D (1–4), together with nine known compounds (5–13), were isolated from the branches and leaves of Croton dongnaiensis (Euphorbiaceae). Their structures were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and the absolute configurations of compounds 1–4 were assigned by comparison of their experimental and TD-DFT calculated ECD spectra. The xanthine oxidase inhibitory activities of compounds 1–13 were evaluated. Compounds 1–6 and 10–13 exhibited moderate inhibitory activities, with IC50 values ranging from 16.08 ± 1.39 to 41.48 ± 1.85 µM, whereas compounds 7–9 showed weak activity (IC50 > 50 µM). These results expand the chemical diversity known from C. dongnaiensis and provide preliminary evidence for the xanthine oxidase inhibitory potential of its isolated constituents.",
  "abstract_shown": true,
  "affiliations": [
    "Basic Science Department, University of Transport and Communications 3 Cau Giay, Lang Hanoi Vietnam",
    "Faculty of Chemical Technology, Hanoi University of Industry 298 Cau Dien, Tay Tuu Hanoi Vietnam",
    "University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Nghia Do Hanoi Vietnam",
    "Institute of Chemistry, VAST 18 Hoang Quoc Viet, Nghia Do Hanoi Vietnam"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tran Thuy Nga"
    },
    {
      "affs": [
        0
      ],
      "name": "Nguyen Thi Mai"
    },
    {
      "affs": [
        0
      ],
      "name": "Bui Thi Mai Anh"
    },
    {
      "affs": [
        1
      ],
      "name": "Nguyen Cong Xuyen"
    },
    {
      "affs": [
        1
      ],
      "name": "Bui Thi Thu Trang",
      "orcid": "0000-0002-5483-9966"
    },
    {
      "affs": [
        2
      ],
      "name": "Phan Hong Quan"
    },
    {
      "affs": [
        3
      ],
      "name": "Nguyen Phuong Thao",
      "orcid": "0009-0004-8428-5556"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3mv3jkp85fft.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08428a",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720775/?tool=EBI",
  "id": "a3mv3jkp85fft",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13720775",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1312|Bioactive Natural Diterpenoids Research"
    ]
  ],
  "openalex": "W7224893809",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720775/pdf/?tool=EBI",
  "pmcid": "PMC13720775",
  "pmid": "42964544",
  "published": "2026-10-30",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/a3mv3jkp85fft.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13720775",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720775"
    },
    {
      "first_seen": "2026-11-03T12:21:35Z",
      "native_id": "PMC13720775",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08428a"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bioactive Natural Diterpenoids Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Crodonsides A–D, four new guaiane-type sesquiterpenoid glycosides from Croton dongnaiensis and their xanthine oxidase inhibitory activities",
  "title_text": "Crodonsides A–D, four new guaiane-type sesquiterpenoid glycosides from Croton dongnaiensis and their xanthine oxidase inhibitory activities",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:35Z",
  "url": "https://research.draconitic.com/paper/a3mv3jkp85fft",
  "venue": "RSC advances",
  "versions": []
}