{
  "abstract": "Objectives\n\nTo evaluate the clinical efficacy and safety of a multispecies probiotic in patients with PsA in moderate disease activity.Methods\n\nIn this single-centre, randomized, double-blind, placebo-controlled trial (RCT), 66 PsA patients with moderate disease activity (Psoriatic Arthritis Disease Activity Score [PASDAS] > 3.2 to <5.4) on stable immunomodulatory therapy were randomized 1:1 to receive either a multispecies (Lactobacillus, Bifidobacterium) probiotic or placebo for 12 weeks. The primary outcome was treatment response at week 12, defined as achieving low disease activity or remission (PASDAS ≤3.2) without treatment change. Secondary outcomes included gut permeability markers, immune cell and microbiome composition. Analyses were conducted per a modified intention-to-treat (only complete cases for primary outcome), with sensitivity analyses using multiple imputation, per-protocol datasets and qPCR-based detection of the probiotic strains in stool (adherence).Results\n\nFifty-six participants were included in the main analysis. Thirteen (43%) participants in the probiotic group and 17 (65%) in the placebo group achieved the primary outcome (P = 0.167). The corresponding odds ratio was 0.4 (95% CI 0.13-1.18). Patient-reported pain and global assessment were the main PASDAS components improving over time, with no between-group differences. No differences were observed in secondary clinical outcomes, gut permeability markers (zonulin, calprotectin, alpha-1-antitrypsin), immune cell profiles or stool microbiome composition between the groups at week 12. No serious adverse events related to the study product were reported.Conclusion\n\nIn this first RCT investigating probiotic supplementation in PsA, probiotic treatment did not show superiority over placebo in achieving treatment response, or altering gut microbiome, or permeability.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria.",
    "Division of Immunology, Otto Loewi research Center, Medical University of Graz, Graz, Austria.",
    "Joint Microbiome Facility, University of Vienna, Vienna, Austria.",
    "Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.",
    "Department of Microbiology and Ecosystem Science, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.",
    "Center for Biomarker Research in Medicine (CBmed), Graz, Austria.",
    "Department of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.",
    "Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Philipp Bosch",
      "orcid": "0000-0002-6783-6422"
    },
    {
      "affs": [
        0
      ],
      "name": "Angelika Lackner",
      "orcid": "0000-0002-2036-9564"
    },
    {
      "affs": [
        0
      ],
      "name": "Barbara Dreo",
      "orcid": "0000-0003-3937-9030"
    },
    {
      "affs": [
        1
      ],
      "name": "Johannes Fessler",
      "orcid": "0000-0002-8841-3795"
    },
    {
      "affs": [
        0
      ],
      "name": "Florentine Moazedi-Fürst",
      "orcid": "0000-0002-2720-8261"
    },
    {
      "affs": [
        0
      ],
      "name": "Rusmir Husic",
      "orcid": "0000-0001-5435-6967"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Joana Séneca",
      "orcid": "0000-0003-3951-3674"
    },
    {
      "affs": [
        0
      ],
      "name": "Andreas Haidmayer"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Vanessa Stadlbauer",
      "orcid": "0000-0001-5508-8271"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Anirudh Subramanian Muralikrishnan",
      "orcid": "0000-0001-7102-9968"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Jens Thiel",
      "orcid": "0000-0001-7582-1514"
    },
    {
      "affs": [
        0
      ],
      "name": "Martin Stradner",
      "orcid": "0000-0002-7884-6626"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3pjwk1za1s7d.bib",
  "cited_by": 0,
  "doi": "10.1093/rheumatology/keag547",
  "fulltext_url": "https://europepmc.org/articles/PMC13656753",
  "id": "a3pjwk1za1s7d",
  "issns": [
    "1462-0324",
    "1462-0332"
  ],
  "landing_url": "https://europepmc.org/article/MED/42832303",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
    ]
  ],
  "openalex": "W7220688399",
  "pdf_url": "https://europepmc.org/articles/PMC13656753?pdf=render",
  "pmcid": "PMC13656753",
  "pmid": "42832303",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a3pjwk1za1s7d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42832303",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42832303"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Spondyloarthritis Studies and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Efficacy and safety of probiotic supplementation in PsA-a randomized controlled trial.",
  "title_text": "Efficacy and safety of probiotic supplementation in PsA-a randomized controlled trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/a3pjwk1za1s7d",
  "venue": "Rheumatology (Oxford, England)",
  "versions": []
}