{
  "abstract": "Introduction\n\nCancer remains a major global health challenge and is a leading cause of morbidity and mortality in Thailand. Industry-sponsored oncology trials (ISOTs) provide critical access to innovative therapies, including targeted agents, immunotherapies (IO), and antibody-drug conjugates (ADCs), particularly in resource-limited settings.Methods\n\nWe conducted a retrospective multicenter study to characterize temporal trends, geographic distribution, and clinical trial characteristics of ISOTs across institutions participating in the Thai Society of Clinical Oncology (TSCO) network between January 2012 and September 2024. Data on trial characteristics, geographic distribution, and patient enrollment were collected from institutions affiliated with the TSCO using a standardized data collection instrument.Results\n\nA total of 651 ISOTs were identified. Analyses were performed using available data for each variable, with complete-case analyses (n = 581) applied where complete trial-level information was required. Most trials were conducted in Bangkok (67%), with academic centers accounting for 84%. Provinces with academic centers hosted more trials than those without (62% vs 27%; P < .001). Lung cancer was the most studied tumor type (39%), followed by breast (15%) and gastroesophageal/gastric cancers (10%). Trial numbers increased over time, with phase III studies predominating (64%), although phase I-II trials rose after 2020. Therapeutic focus shifted from chemotherapy to targeted therapies, IO, and ADCs. Sponsorship remained primarily Western, with increasing contributions from Asian companies, particularly China.Conclusion\n\nWithin participating TSCO-affiliated institutions, ISOTs were largely concentrated in major urban academic centers, particularly Bangkok. While phase III trials remain predominant, early-phase studies and sponsorship from Asian companies have increased. These findings highlight an evolving oncology research landscape and ongoing disparities in trial distribution.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Faculty of Medicine, Khon Kaen University-Srinagarind Hospital, Khon Kaen, Thailand.",
    "Department of Medicine, Police General Hospital, Bangkok, Thailand.",
    "Department of Medicine, Sunpasitthiprasong Hospital, Ubonratchathani, Thailand.",
    "Department of Medicine, Srinakharinwirot University-Faculty of Medicine - Ongkharak Campus, Nakhon Nayok, Thailand.",
    "Division of Medical Oncology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
    "Department of Oncology, Prince of Songkla University-Faculty of Medicine, Songkhla, Thailand.",
    "Department of Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.",
    "Department of Medicine, Oncology Unit, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.",
    "Division of Medical Oncology, Department of Medicine, King Chulalongkorn Memorial Hospital-Thai Red Cross Society, Bangkok, Thailand.",
    "Department of Medicine, Buddhachinaraj Hospital, Pitsanulok, Thailand.",
    "Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.",
    "Division of Medical Oncology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.",
    "Department of Oncology, Ubonratchathani Cancer Hospital, Ubonratchathani, Thailand.",
    "Department of Medicine, Sisaket Hospital, Sisaket, Thailand.",
    "Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.",
    "Department of Medicine, Lampang Hospital, Nakhon Lampang, Thailand.",
    "Department of Medicine, Medical Oncology Unit, Phrapokklao Cancer Center of Excellence, Chanthaburi, Thailand.",
    "Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, 270 Rama 6 Rd., Ratchathewi, Bangkok, 10400, Thailand. nuttapong.nga@mahidol.ac.th."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kosin Wirasorn"
    },
    {
      "affs": [
        1
      ],
      "name": "Jirapath Wiwitkeyoonwong"
    },
    {
      "affs": [
        2
      ],
      "name": "Jitlada Juengsamarn"
    },
    {
      "affs": [
        3
      ],
      "name": "Chanchai Charonpongsuntorn"
    },
    {
      "affs": [
        4
      ],
      "name": "Pongwut Danchaivijitr"
    },
    {
      "affs": [
        5
      ],
      "name": "Arunee Dechaphunkul"
    },
    {
      "affs": [
        6
      ],
      "name": "Nuttinee Inworn"
    },
    {
      "affs": [
        7
      ],
      "name": "Kunlatida Maneenil"
    },
    {
      "affs": [
        8
      ],
      "name": "Napa Parinyanitikul"
    },
    {
      "affs": [
        9
      ],
      "name": "Narichaya Phattana"
    },
    {
      "affs": [
        10
      ],
      "name": "Parichat Phongthai"
    },
    {
      "affs": [
        11
      ],
      "name": "Naiyarat Prasongsook"
    },
    {
      "affs": [
        12
      ],
      "name": "Isaraporn Sangsaikaew"
    },
    {
      "affs": [
        13
      ],
      "name": "Chatsuda Sookthon"
    },
    {
      "affs": [
        14
      ],
      "name": "Jirawat Thanestada"
    },
    {
      "affs": [
        15
      ],
      "name": "Kijjakom Thanasombunsukh"
    },
    {
      "affs": [
        16
      ],
      "name": "Passakorn Wanchaijiraboon"
    },
    {
      "affs": [
        4
      ],
      "name": "Charuwan Akewanlop"
    },
    {
      "affs": [
        17
      ],
      "name": "Nuttapong Ngamphaiboon",
      "orcid": "0000-0002-6535-6345"
    },
    {
      "name": "TSCO"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3sem1vz60c4z.bib",
  "cited_by": 0,
  "doi": "10.1186/s12885-026-16583-1",
  "fulltext_url": "https://europepmc.org/articles/PMC13721189",
  "id": "a3sem1vz60c4z",
  "issns": [
    "1471-2407"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958159",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
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      "openalex",
      "3004|Pharmaceutical industry and healthcare"
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  "pdf_url": "https://europepmc.org/articles/PMC13721189?pdf=render",
  "pmcid": "PMC13721189",
  "pmid": "42958159",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/a3sem1vz60c4z.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958159",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958159"
    },
    {
      "first_seen": "2026-11-03T12:21:55Z",
      "native_id": "PMC13721189",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12885-026-16583-1"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3004|Pharmaceutical industry and healthcare",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Landscape of industry-sponsored oncology trials across the Thai Society of Clinical Oncology (TSCO): a 12-year multicenter analysis.",
  "title_text": "Landscape of industry-sponsored oncology trials across the Thai Society of Clinical Oncology (TSCO): a 12-year multicenter analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:55Z",
  "url": "https://research.draconitic.com/paper/a3sem1vz60c4z",
  "venue": "BMC cancer",
  "versions": []
}