{
  "abstract": "Rapidly proliferating cancer cells display an elevated demand for vitamin B12, rendering this bacterial‐derived cofactor an attractive targeting motif for nanotherapeutic drug delivery. Herein, we report a concise two‐step synthesis of a polymerizable 5′‐modified vitamin B12 ‐monomer that enables the covalent integration of B12 into pH‐ and redox‐responsive nanogels. The resulting nanogels efficiently encapsulate doxorubicin through electrostatic interactions between the cationic drug and the anionic nanogel network, while enabling stimuli‐responsive drug release under tumor‐relevant conditions. In vitro studies revealed that DOX@B12‐nanogels retain potent antiproliferative activity against HT‐29 colorectal cancer cells (IC50 = 0.878 ± 0.102 μM), while decreasing cytotoxicity toward healthy CCD 841 CoN cells by 34‐fold relative to non‐B12‐functionalized control nanogels. These findings establish covalently engineered vitamin B12‐nanogels as a promising platform for selective and stimuli‐responsive anticancer drug delivery.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Chemistry University of Warsaw Warsaw Poland",
    "Biological and Chemical Research Center University of Warsaw Warsaw Poland",
    "Department of Chemistry University of Zürich Zürich Switzerland",
    "Department of Molecular Biology, Institute of Biochemistry, Faculty of Biology University of Warsaw Warsaw Poland",
    "Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry Gdańsk University of Technology Gdańsk Poland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Serife Dagdelen"
    },
    {
      "affs": [
        2
      ],
      "name": "Paula D. Mestizo",
      "orcid": "0000-0001-7767-7982"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcin Mackiewicz",
      "orcid": "0000-0003-2897-8724"
    },
    {
      "affs": [
        4
      ],
      "name": "Agnieszka Kurdyn",
      "orcid": "0000-0002-6650-2738"
    },
    {
      "affs": [
        4
      ],
      "name": "Ewa Augustin",
      "orcid": "0000-0002-0807-021X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Marcin Karbarz",
      "orcid": "0000-0002-7813-0513"
    },
    {
      "affs": [
        2
      ],
      "name": "Felix Zelder",
      "orcid": "0000-0002-1473-8570"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a3xkzr6eyh5ed.bib",
  "cited_by": 0,
  "doi": "10.1002/cbic.70580",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698639/",
  "id": "a3xkzr6eyh5ed",
  "issns": [
    "1439-4227",
    "1439-7633"
  ],
  "landing_url": "https://doi.org/10.1002/cbic.70580",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7223691397",
  "pdf_url": "https://europepmc.org/articles/PMC13698639?pdf=render",
  "pmcid": "PMC13698639",
  "pmid": "42929280",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a3xkzr6eyh5ed.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:29Z",
      "native_id": "PMC13698639",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbic.70580"
    },
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929280",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929280"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery",
  "title_text": "Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:28Z",
  "url": "https://research.draconitic.com/paper/a3xkzr6eyh5ed",
  "venue": "Chembiochem",
  "versions": []
}