{
  "abstract": "Many cancers evade immunity by converting neutrophils into polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), but the chromatin mechanisms that maintain this pathological state remain unclear. Here we show that tumor-induced suppressive neutrophils depend on mSWI/SNF chromatin remodeling. Two orally bioavailable mSWI/SNF ATPase antagonists, a degrader and a catalytic inhibitor, produced immune-dependent tumor control across syngeneic models, including tumors resistant to PD-1 blockade, and enhanced checkpoint therapy without overt toxicity. Treatment rapidly depleted intratumoral PMN-MDSCs, restored functional CD8+ T cells, and blocked tumor explant-induced expansion and suppressive activity of mouse and human PMN-MDSCs. mSWI/SNF antagonism collapsed chromatin accessibility and PU.1/C/EBP{beta} occupancy at regulatory elements that sustain PMN-MDSC identity. Thus, suppressive neutrophils harbor a druggable chromatin vulnerability that can be exploited to restore cancer immunity.",
  "abstract_shown": true,
  "affiliations": [
    "University of Michigan"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 32,
  "authors": [
    {
      "name": "F. Yang"
    },
    {
      "name": "Y. Bao"
    },
    {
      "name": "Y. Qiao"
    },
    {
      "name": "G. Cruz"
    },
    {
      "name": "E. Young"
    },
    {
      "name": "R. Mannan"
    },
    {
      "name": "Y. Zhang"
    },
    {
      "name": "M. Goodrich"
    },
    {
      "name": "Y. Cao"
    },
    {
      "name": "J. Luo"
    },
    {
      "name": "R. Paturu"
    },
    {
      "name": "S. Mahapatra"
    },
    {
      "name": "J. C.-Y. Tien"
    },
    {
      "name": "R. Xu"
    },
    {
      "name": "M. Kobayashi"
    },
    {
      "name": "Y. Liu"
    },
    {
      "name": "A. Coleski"
    },
    {
      "name": "F. Su"
    },
    {
      "name": "X. Cao"
    },
    {
      "name": "S. J. Miner"
    },
    {
      "name": "L. Vatan"
    },
    {
      "name": "R. Sudharshan"
    },
    {
      "name": "A. Rao"
    },
    {
      "name": "S. Samajdar"
    },
    {
      "name": "C. Abbineni"
    },
    {
      "name": "M. Ramachandra"
    },
    {
      "name": "J. C. Piel"
    },
    {
      "name": "M. Hentemann"
    },
    {
      "name": "I. Kryczek"
    },
    {
      "name": "W. Zou"
    },
    {
      "name": "L. Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "A. M. Chinnaiyan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a47vjpmrab6d8.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.26.754703",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754703v1.full",
  "id": "a47vjpmrab6d8",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754703v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "2403|Immune cells in cancer"
    ]
  ],
  "openalex": "W7214610535",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754703v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a47vjpmrab6d8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:52Z",
      "native_id": "10.64898/2026.09.26.754703",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754703v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity",
  "title_text": "A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:52Z",
  "url": "https://research.draconitic.com/paper/a47vjpmrab6d8",
  "venue": "bioRxiv",
  "versions": []
}