{
  "abstract": "Cardiac function is modulated by the intrinsic cardiac nervous system (ICNS), which integrates autonomic signals and undergoes remodeling in pathological conditions. Here, we demonstrate that adult rodent ICNS ganglia harbor neural stem-like cells that proliferate in vitro, form neurospheres, self-renew, and generate neurons expressing βIII-tubulin and PGP 9.5. In vivo, cells expressing the stem cell marker SOX2 are detected within ICNS ganglia. Moreover, cardiac injury induced by monocrotaline increases the number of SOX2-positive cells expressing the cell cycle marker Ki67 and the number of EdU-incorporating, nestin-expressing cells within the ICNS. Together, our data provide the first evidence of neural stem-like cells in adult ICNS ganglia and suggest their potential role in cardiac neuroplasticity.",
  "abstract_shown": true,
  "affiliations": [
    "PReTI Laboratory, UR 24184, University of Poitiers, Poitiers, France.",
    "Université Paris-Saclay, INSERM, UMR_S 1358, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France.",
    "Department of Preclinical Research, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.",
    "4CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, UR 22751, CEDEX 09, University of Poitiers, Poitiers, France.",
    "Department of Medicine, Faculty of Medicine, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec, Canada."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alice Jean"
    },
    {
      "affs": [
        0
      ],
      "name": "Guenaelle Lizot"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Mathieu Gourmelon"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabrice Antigny"
    },
    {
      "affs": [
        3
      ],
      "name": "Laetitia Cousin"
    },
    {
      "affs": [
        3
      ],
      "name": "Michela Crotti"
    },
    {
      "affs": [
        3
      ],
      "name": "Patricia Arnault"
    },
    {
      "affs": [
        0
      ],
      "name": "Jocelyn Bescond"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrick Bois"
    },
    {
      "affs": [
        3
      ],
      "name": "Bruno Constantin",
      "orcid": "0000-0003-1668-581X"
    },
    {
      "affs": [
        3
      ],
      "name": "Valerie Coronas"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Aurelien Chatelier",
      "orcid": "0000-0002-7441-1182"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4b0md78ychnm.bib",
  "cited_by": 0,
  "doi": "10.1096/fj.202601054r",
  "fulltext_url": "https://europepmc.org/articles/PMC13717282",
  "id": "a4b0md78ychnm",
  "issns": [
    "0892-6638",
    "1530-6860"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952306",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Letter"
    ],
    [
      "openalex",
      "2806|Neurogenesis and neuroplasticity mechanisms"
    ]
  ],
  "openalex": "W7224341595",
  "pdf_url": "https://europepmc.org/articles/PMC13717282?pdf=render",
  "pmcid": "PMC13717282",
  "pmid": "42952306",
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a4b0md78ychnm.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42952306",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952306"
    },
    {
      "first_seen": "2026-11-02T12:21:37Z",
      "native_id": "PMC13717282",
      "source": "pmc",
      "url": "https://doi.org/10.1096/fj.202601054r"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2806|Neurogenesis and neuroplasticity mechanisms",
      "subfield": "neuroscience"
    }
  ],
  "title": "Evidence for the Existence of Neural Stem-Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia.",
  "title_text": "Evidence for the Existence of Neural Stem-Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:37Z",
  "url": "https://research.draconitic.com/paper/a4b0md78ychnm",
  "venue": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
  "versions": []
}