{
  "abstract": "Fluorinated bicyclo[1.1.1]pentanes (F-BCPs) are valuable three-dimensional bioisosteres in drug discovery, yet methods for the direct construction of bridge-monofluorinated and quaternary F-BCPs remain scarce. Here, we report a fluoroiodocarbene addition to bicyclobutanes under mild conditions, providing 2-fluoro-2-iodobicyclo[1.1.1]pentanes. The C-I bond serves as a versatile radical handle, enabling synthesis of quaternary bridge-fluorinated BCPs, including Giese-type additions to activated alkenes and desulfonylative couplings. This strategy offers a practical, modular entry to bridge-fluorinated BCP architectures of potential interest for medicinal chemistry.",
  "abstract_shown": true,
  "affiliations": [
    "National Institute of Research and Innovation, Aizkraukles Street 21, LV-1006Riga, Latvia.",
    "Faculty of Medicine and Life Sciences, University of Latvia, Jelgavas Street 1, LV-1004Riga, Latvia.",
    "Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena Street 3, LV-1048Riga, Latvia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arturs Sperga"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Toms Pfeifers"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Artis Kinens"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Janis Veliks",
      "orcid": "0000-0003-0955-8257"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4gmrr5qb6d0m.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03112",
  "fulltext_url": "https://europepmc.org/articles/PMC13595906",
  "id": "a4gmrr5qb6d0m",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42918071",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7210293393",
  "pdf_url": "https://europepmc.org/articles/PMC13595906?pdf=render",
  "pmcid": "PMC13595906",
  "pmid": "42918071",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a4gmrr5qb6d0m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42918071",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42918071"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Fluoroiodocarbene Addition to Bicyclobutanes: A Radical Handle for Quaternary Fluorinated Bicyclo[1.1.1]pentanes.",
  "title_text": "Fluoroiodocarbene Addition to Bicyclobutanes: A Radical Handle for Quaternary Fluorinated Bicyclo[1.1.1]pentanes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/a4gmrr5qb6d0m",
  "venue": "Organic letters",
  "versions": []
}