{
  "abstract": "MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression, yet predicted miRNA target interactions often require experimental validation. TargetScan Fly predicts that both miR-10-3p and miR-1006-3p target the Drosophila RNA-binding protein Mei-P26, a critical regulator of germline development and miRNA biogenesis. Here, we experimentally demonstrate that overexpression of miR-10-3p is sufficient to significantly suppress mei-P26 mRNA level in the testis. Consistently, inhibition of miR-10 using sponge increased mei-P26 positive spermatocytes in testis. Together, these findings suggest that miR-10-3p, but not miR-1006-3p, functionally regulates mei-P26 in Drosophila testis, highlighting selective engagement of canonical miRNA pathways in mei-P26 regulation.",
  "abstract_shown": true,
  "affiliations": [
    "Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, United States",
    "Saint Joseph's Academy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shallinie Thangadurai"
    },
    {
      "affs": [
        0
      ],
      "name": "Elena Pak"
    },
    {
      "affs": [
        1
      ],
      "name": "Isabella Hammock"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexander Murashov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4jakepctq36b.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002187",
  "fulltext_url": "https://www.micropublication.org/journals/biology/micropub-biology-002187",
  "id": "a4jakepctq36b",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://doi.org/10.17912/micropub.biology.002187",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7204801372",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Caltech Library",
  "ris": "https://research.draconitic.com/paper/a4jakepctq36b.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:02Z",
      "native_id": "0dbd627925dc48ed8b107a605cf8ea81",
      "source": "doaj",
      "url": "https://doi.org/10.17912/micropub.biology.002187"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "miR-10-3p, but not miR-1006-3p, regulates mei-P26 expression in the Drosophila testis",
  "title_text": "miR-10-3p, but not miR-1006-3p, regulates mei-P26 expression in the Drosophila testis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:16Z",
  "url": "https://research.draconitic.com/paper/a4jakepctq36b",
  "venue": "microPublication Biology",
  "versions": []
}