{
  "abstract": "Tumor microenvironment is closely involved in breast cancer progression and metastatic spread. Therefore, it is essential to develop a combination therapy to suppress tumor progression by regulating TME. Herein, Ru486-loaded doxorubicin (DOX)–chondroitin sulfate (chondroitin sulfate) nanomicelles (R/D-CS) were prepared for combined delivery. A “MCF-7 + MRC-5” dual-cell model and “4T1 + NIH-3T3” cell-bearing mouse model were established to recapitulate TME in vitro and in vivo, respectively. Interestingly, R/D-CS nanomicelles internalized cancer-associated fibroblasts and tumor cells and reduced tumor proliferation and migration markedly by downregulating expression of P-gp, vimentin, and CXCR4. Moreover, the in vivo antitumor studies were performed on a tumor-bearing mouse model, R/D-CS nanomicelles showed stronger antiproliferative and antimetastatic effects. Overall, the combination therapy based on R/D-CS nanomicelles was potent for breast cancer treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Weifang University of Science and Technology , , ,",
    "Weifang People’s Hospital , , ,",
    "Weifa ng People’s Hospital , , ,",
    "Jining University , , , ,",
    "Luoyang Normal University , , ,",
    "Gaomi People’s Hospital , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingliang Wu",
      "orcid": "0000-0001-6962-2842"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Na Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Di Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shujie Sun"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Zhang",
      "orcid": "0000-0001-6070-8316"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhipeng Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Pei Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yueliang Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Qian Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4rq77g4w2x0e.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.5c05935",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718202/?tool=EBI",
  "id": "a4rq77g4w2x0e",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/42/64339/5450558/Microenvironmental-Regulated-Chondroitin-Sulfate",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7221797271",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c05935",
  "pmcid": "PMC13718202",
  "pmid": "42959729",
  "published": "2026-10-13",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/a4rq77g4w2x0e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.5c05935",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/42/64339/5450558/Microenvironmental-Regulated-Chondroitin-Sulfate"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718202",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718202"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959729",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959729"
    },
    {
      "first_seen": "2026-11-02T12:22:17Z",
      "native_id": "PMC13718202",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.5c05935"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Microenvironmental-Regulated Chondroitin Sulfate Nanomicelles for Inhibition of Breast Cancer Drug Resistance and Metastasis",
  "title_text": "Microenvironmental-Regulated Chondroitin Sulfate Nanomicelles for Inhibition of Breast Cancer Drug Resistance and Metastasis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:17Z",
  "url": "https://research.draconitic.com/paper/a4rq77g4w2x0e",
  "venue": "ACS Omega",
  "versions": []
}