{
  "abstract": "Allogeneic hematopoietic cell transplantations (allo-HCT) is a procedure with long history and well-documented efficacy in treating various malignant and non-malignant diseases of the hematopoietic system. While there is a potential for late complications even over 10 years following allo-HCT, the data on longer observations are limited due to loss in follow-up, personnel and organizational changes in transplant centers, and focusing on new promising therapies instead of HCT. The study aimed to evaluate 15- and 20-year overall and progression-free survival of allo-HCT recipients in our center. During the inclusion period from 1999 to 2014, we identified 269 allo-HCT recipients. Survival analyses were performed using Kaplan–Meier curves, the Cox proportional hazards model, and the log-rank test. First, we evaluated 15- and 20-year survival rates for the entire cohort of allo-HCT recipients from matched related donor (MRD) and matched unrelated donor (MUD). Then we performed similar analyses for allo-HCT recipients due to acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), myelodysplastic neoplasms (MDS), non-Hodgkin lymphomas (NHL), and severe aplastic anemia (SAA). It was confirmed that survival benefit continues also during long-term observation. Notably, the plateau effect of PFS was often observed over 20 years following allo-HCT, implying the ability to cure in a relatively large group of patients with otherwise incurable diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Ul. Banacha 1A, 02-097 Warsaw, Poland",
    "Doctoral School of the Medical University of Warsaw, Ul. Żwirki I Wigury 61, 02-091 Warsaw, Poland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kajetan Karaszewski",
      "orcid": "0009-0006-2112-1698"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakub Góra",
      "orcid": "0009-0003-3299-8143"
    },
    {
      "affs": [
        0
      ],
      "name": "Monika Paluszewska"
    },
    {
      "affs": [
        0
      ],
      "name": "Elżbieta Urbanowska"
    },
    {
      "affs": [
        0
      ],
      "name": "Ewa Karakulska-Prystupiuk",
      "orcid": "0000-0002-0201-5041"
    },
    {
      "affs": [
        0
      ],
      "name": "Piotr Boguradzki",
      "orcid": "0000-0002-3915-1928"
    },
    {
      "affs": [
        0
      ],
      "name": "Agnieszka Tomaszewska",
      "orcid": "0000-0001-5485-3680"
    },
    {
      "affs": [
        0
      ],
      "name": "Grzegorz Władysław Basak",
      "orcid": "0000-0003-3858-8180"
    },
    {
      "affs": [
        0
      ],
      "name": "Wiesław Wiktor Jędrzejczak",
      "orcid": "0000-0002-6813-3331"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4s5czatptjty.bib",
  "cited_by": 0,
  "doi": "10.1007/s12015-026-11241-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719751/",
  "id": "a4s5czatptjty",
  "issns": [
    "2629-3269",
    "2629-3277"
  ],
  "landing_url": "https://doi.org/10.1007/s12015-026-11241-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7213979144",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s12015-026-11241-2.pdf",
  "pmcid": "PMC13719751",
  "pmid": "42771262",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a4s5czatptjty.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:39Z",
      "native_id": "PMC13719751",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12015-026-11241-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Hematopoietic Stem Cell Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Long-term Results of Allogeneic Hematopoietic Cell Transplantation (allo-HCT): Real-life Data of 15- and 20-year Survivals from a Single Center",
  "title_text": "Long-term Results of Allogeneic Hematopoietic Cell Transplantation (allo-HCT): Real-life Data of 15- and 20-year Survivals from a Single Center",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:45Z",
  "url": "https://research.draconitic.com/paper/a4s5czatptjty",
  "venue": "Stem Cell Reviews and Reports",
  "versions": []
}