{
  "abstract": "The NLRP3 inflammasome is a cytosolic signaling platform that drives caspase-1-dependent maturation of IL-1β and IL-18 and gasdermin D (GSDMD)-mediated pyroptosis. During infection with major porcine viruses – including African swine fever virus, porcine reproductive and respiratory syndrome virus, pseudorabies virus, porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine circovirus type 2, NLRP3 exerts opposing effects: moderate activation restricts viral propagation, whereas sustained stimulation drives tissue injury. We review how structurally unrelated viral proteins converge on limited upstream events – endolysosomal damage, ion flux, mitochondrial injury, ER stress, and the ubiquitin–autophagy network. Because genetically distinct porcine pathogens exploit this same regulatory axis, it represents a shared point of vulnerability. We assess therapeutic options targeting NLRP3 assembly, GSDMD pore formation, and host proteostasis, and highlight questions requiring validation in porcine cells and pigs.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan Province, China",
    "Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs, Zhengzhou, Henan Province, China",
    "Key Laboratory of Veterinary Biotechnology of Henan Province, Henan Agricultural University, Zhengzhou, Henan Province, China",
    "Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Agricultural University, Zhengzhou, Henan Province, China",
    "Longhu Advanced Immunization Laboratory, Henan Agricultural University, Zhengzhou, Henan Province, China",
    "International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, Henan Province, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ya-Di Guo"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Hang-Tian Mei"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yang Wang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yu-Xin Xiang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ying-Nan Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Guo-Yu Yang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jiang Wang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lei Zeng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Bei-Bei Chu",
      "orcid": "0000-0003-2961-4754"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Sheng-Li Ming",
      "orcid": "0000-0002-7505-6143"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a4w9hjt8ey0cy.bib",
  "cited_by": 0,
  "doi": "10.1080/21505594.2026.2753323",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733211/",
  "id": "a4w9hjt8ey0cy",
  "issns": [
    "2150-5594",
    "2150-5608"
  ],
  "landing_url": "https://doi.org/10.1080/21505594.2026.2753323",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "heading",
      "Viral Pathogenesis"
    ],
    [
      "openalex",
      "1312|Inflammasome and immune disorders"
    ]
  ],
  "openalex": "W7224766748",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/21505594.2026.2753323?needAccess=true",
  "pmcid": "PMC13733211",
  "pmid": "42958756",
  "published": "2026-10-29",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/a4w9hjt8ey0cy.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:03Z",
      "native_id": "PMC13733211",
      "source": "pmc",
      "url": "https://doi.org/10.1080/21505594.2026.2753323"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Inflammasome and immune disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "NLRP3 inflammasome in major swine viral infections: Host defense and viral antagonism",
  "title_text": "NLRP3 inflammasome in major swine viral infections: Host defense and viral antagonism",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:03Z",
  "url": "https://research.draconitic.com/paper/a4w9hjt8ey0cy",
  "venue": "Virulence",
  "versions": []
}