{
  "abstract": "Forest musk deer (Moschus berezovskii), a nationally protected species, has experienced a rapid population decline, highlighting the need to improve captive breeding strategies. Captive individuals are more susceptible to gastrointestinal disorders than wild individuals, making dietary regulation important for intestinal health. Wall-broken yeast (BWY) powder, has attracted increasing attention as a functional feed additive due to its potential roles in regulating intestinal health, microbial composition, and host metabolism. This study evaluated the effects of wall-broken yeast powder on gut microbiota, and serum metabolome in forest musk deer. Fourteen healthy male forest musk deer aged 4.5 years, were randomly assigned to two groups (n = 7). The CK group was fed a basal diet, whereas the BWY group was fed the basal diet supplemented with 15 g/kg DM wall-broken yeast powder for a 7 d adaptation period and a 30 d experimental period. 16S rDNA sequencing showed that BWY supplementation altered gut microbial community structure based on β-diversity analysis, with Ruminobacter, UCG-005, and Bacteroides showing increased relative abundance in the BWY group. Serum metabolomics identified 69 differential metabolites between the CK and BWY groups (VIP > 1 and P < 0.05), with upregulated metabolites mainly enriched in amino acids and their metabolites, hormones and hormone-related substances, and glycerophospholipids. Key metabolic pathways included ABC transporters, glycerophospholipid metabolism, phenylalanine metabolism, and β-alanine metabolism. Correlation analysis showed that Prevotellaceae_UCG-004 was positively associated with serum salidroside levels, whereas Ruminobacter was positively correlated with quinolinic acid, Lys-Gly, Gly-Lys, and Cyclo(Pro-Leu) levels (P < 0.05). Overall, wall-broken yeast powder supplementation may modulate gut microbial composition and affect amino acid metabolism in forest musk deer.",
  "abstract_shown": true,
  "affiliations": [
    "College of Smart Agriculture, Chongqing University of Arts and Sciences, Chongqing, China",
    "Chongqing Institute of Medicinal Plant Cultivation, Chongqing University of Chinese Medicine, Chongqing, China",
    "Department of Ophthalmology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yongjiang Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianjun Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zaixiang Ying"
    },
    {
      "affs": [
        0
      ],
      "name": "Shan Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Ningqian Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingcheng Cai"
    },
    {
      "affs": [
        1
      ],
      "name": "Dejun Zeng"
    },
    {
      "affs": [
        1
      ],
      "name": "Chenglu Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qiuping Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Siqi Peng"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhonggui Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qinlin Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a529zhvgb05xa.bib",
  "cited_by": 0,
  "doi": "10.3389/fvets.2026.1978027",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735546/",
  "id": "a529zhvgb05xa",
  "issns": [
    "2297-1769"
  ],
  "landing_url": "https://doi.org/10.3389/fvets.2026.1978027",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "1103|Animal Nutrition and Physiology"
    ]
  ],
  "openalex": "W7223176052",
  "pdf_url": "https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1978027/pdf",
  "pmcid": "PMC13735546",
  "pmid": "42990863",
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a529zhvgb05xa.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:12Z",
      "native_id": "PMC13735546",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fvets.2026.1978027"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Nutrition and Physiology",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Effects of Wall-broken yeast powder on gut microbiota and serum metabolome in captive forest musk deer (Moschus bere-zovskii)",
  "title_text": "Effects of Wall-broken yeast powder on gut microbiota and serum metabolome in captive forest musk deer (Moschus bere-zovskii)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:12Z",
  "url": "https://research.draconitic.com/paper/a529zhvgb05xa",
  "venue": "Frontiers in Veterinary Science",
  "versions": []
}