{
  "abstract": "Background/Objectives: Oral health may be affected by chronic kidney disease (CKD) through mechanisms including uremic toxin accumulation, immune dysregulation, and treatment-related factors, although these relationships remain poorly understood. This study aimed to describe oral health according to CKD stages (2-5) and to explore its association with disease progression, as well as one-year changes in oral, renal, and inflammatory parameters and oral health-related quality of life. Methods: The NephroDent study is a prospective cohort study including patients with non-dialysis CKD stages 2 to 5. Oral, clinical, and biological parameters and quality of life were assessed at baseline and after one year. Baseline characteristics were compared across CKD stages, and changes were analyzed according to self-reported dental care. Results: Eighty-seven patients were included. Oral health impairment was observed across all CKD stages, including stages 2 and 3, with substantial periodontal treatment needs and periodontal pockets ≥ 6 mm. Dental and periodontal parameters varied across stages, with some indicators showing numerically poorer values in stages 4-5, but no significant differences were observed between CKD stages. Over one year, changes in oral health indices, renal function (eGFR), inflammatory markers, and quality of life did not differ significantly according to dental care. Conclusions: Oral health impairment was observed across all CKD stages, including early disease, despite preserved quality of life. No significant short-term association was found between dental care and changes in oral or systemic parameters. Further studies are needed to clarify the role of oral health in CKD progression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oral Surgery, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France.",
    "Laboratoire de Bioingénierie Tissulaire, Institut National de la Santé et de la Recherche Médicale, University of Bordeaux, U1026, F-33000 Bordeaux, France.",
    "Bordeaux Sciences Agro, Bordeaux INP, INRAE, University of Bordeaux, UMR 1366, OENO, ISVV, F-33140 Villenave d'Ornon, France.",
    "Pôle de Médecine et Chirurgie Bucco-Dentaire, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France.",
    "Bordeaux Population Health, Institut National de la Santé et de la Recherche Médicale, University of Bordeaux, U1219, F-33000 Bordeaux, France.",
    "Clinical Epidemiology Unit (USMR), Pôle de Santé Publique, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France.",
    "Department of Clinical Research and Innovation, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France.",
    "Unit of Nephrology, Service de Néphrologie, Dialyse, Transplantation et Aphérèses, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sylvain Catros",
      "orcid": "0000-0002-3419-3467"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Johan Samot",
      "orcid": "0000-0002-6087-2375"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Virginie Chuy",
      "orcid": "0000-0002-1600-7931"
    },
    {
      "affs": [
        5
      ],
      "name": "Eléonore Tron"
    },
    {
      "affs": [
        6
      ],
      "name": "Fideline Collin"
    },
    {
      "affs": [
        5
      ],
      "name": "Antoine Bénard"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "Claire Rigothier",
      "orcid": "0000-0002-5569-5562"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a53mca472f2dw.bib",
  "cited_by": 0,
  "doi": "10.3390/dj14100646",
  "fulltext_url": "https://europepmc.org/articles/PMC13703155",
  "id": "a53mca472f2dw",
  "issns": [
    "2304-6767"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930412",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "3506|Oral microbiology and periodontitis research"
    ]
  ],
  "openalex": "W7220841210",
  "pdf_url": "https://europepmc.org/articles/PMC13703155?pdf=render",
  "pmcid": "PMC13703155",
  "pmid": "42930412",
  "published": "2026-10-07",
  "publisher": "MDPI",
  "ris": "https://research.draconitic.com/paper/a53mca472f2dw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930412",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930412"
    },
    {
      "first_seen": "2026-11-10T12:20:54Z",
      "native_id": "hal-05858040",
      "source": "hal",
      "url": "https://hal.science/hal-05858040v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Evaluation of Oral Health in Early Stages of Chronic Kidney Disease.",
  "title_text": "Evaluation of Oral Health in Early Stages of Chronic Kidney Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-11T12:21:02Z",
  "url": "https://research.draconitic.com/paper/a53mca472f2dw",
  "venue": "Dentistry journal",
  "versions": []
}