{
  "abstract": "Heart transplantation following donation after controlled circulatory death (DCD) could alleviate the global shortage of organs. We assessed the cost-effectiveness of this strategy and outlined the factors enabling an efficient DCD heart program. Two strategies were compared: donation after brain death (DBD) using static cold storage vs. DBD + DCD transplantation, where DCD hearts are preserved with a normothermic ex situ perfusion system. Costs (€; 2024 value) and outcomes (quality-adjusted life years (QALYs)) were modelled through a 15-year time horizon. Our main assumption was that DCD would increase transplant access without affecting waitlist mortality, with equivalent post-transplant outcomes. With a 20% annual increase in transplant activity, the DBD + DCD strategy resulted in a mean incremental gain of 0.14 QALYs at an additional cost of €20,618 compared with DBD alone. The incremental cost-effectiveness ratio was €146,373 per QALY gained. An 8% relative reduction in waitlist mortality (i.e., four additional lives saved annually among 500 new waitlisted patients) would make the DCD heart program cost-effective at €100,000 per QALY. Lower consumable costs would further improve cost-effectiveness. Decision-makers should consider these findings in light of the disease severity and the persistent shortage of heart donors that could be alleviated with DCD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Jamal Atfeh"
    },
    {
      "name": "Pascale Guerre"
    },
    {
      "name": "Julien Guihaire"
    },
    {
      "name": "Laurent Sebbag"
    },
    {
      "name": "Matteo Pozzi"
    },
    {
      "name": "Laure Huot"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a567xvymv3sxx.bib",
  "cited_by": 0,
  "doi": "10.3389/ti.2026.17149",
  "fulltext_url": null,
  "id": "a567xvymv3sxx",
  "issns": [
    "0934-0874",
    "1432-2277"
  ],
  "landing_url": "https://hal.science/hal-05799802v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2746|Transplantation: Methods and Outcomes"
    ]
  ],
  "openalex": "W7212005612",
  "pdf_url": "https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.17149/pdf",
  "pmcid": null,
  "pmid": "42780164",
  "published": "2026-09-09",
  "publisher": "Frontiers Media",
  "ris": "https://research.draconitic.com/paper/a567xvymv3sxx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05799802",
      "source": "hal",
      "url": "https://hal.science/hal-05799802v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Modeling the cost-effectiveness of introducing donation after controlled circulatory death for heart transplantation in France",
  "title_text": "Modeling the cost-effectiveness of introducing donation after controlled circulatory death for heart transplantation in France",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/a567xvymv3sxx",
  "venue": "Transplant International",
  "versions": []
}