{
  "abstract": "This review asked which maternal–infant clinical decisions are plausible targets for CRISPR diagnostics, what evidence currently supports those roles, and what validation remains necessary. We conducted a structured narrative review of CRISPR diagnostics for HIV, hepatitis B virus (HBV), and syphilis, evaluating complete specimen-to-result systems rather than isolated nuclease reactions. Across the studies identified, HIV early infant diagnosis (EID) had the strongest near-term clinical rationale but lacked validation of microvolume whole blood or dried blood spots, broad HIV-1 inclusivity, and integrated process controls. Maternal HBV had the broadest clinical-specimen evidence, but no identified study established IU/mL-traceable classification around a pregnancy prophylaxis decision boundary. Syphilis direct detection supported a narrower specimen- and stage-dependent adjunctive role and could not replace antenatal serology or exclude congenital infection when negative. Major cross-cutting gaps included specimen preparation, calibration, contamination containment, invalid-result detection, and multisite intended-use validation. These findings do not establish routine clinical readiness. As an evidence-informed development priority, a shared service platform with separately validated pathogen-specific assays appears more defensible in the near term than a universal single-tube triplex.",
  "abstract_shown": true,
  "affiliations": [
    "West China Hospital Sichuan University Jintang Hospital, Jintang First People’s Hospital",
    "Department of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi",
    "The Second Affiliated Hospital of Guizhou, University of Traditional Chinese Medicine",
    "Public Health Clinical Center of Chengdu"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hongzhi Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Lanke Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Fukang Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoxue Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Qiujie Yu"
    },
    {
      "affs": [
        3
      ],
      "name": "Qianyi Li"
    },
    {
      "affs": [
        1
      ],
      "name": "He Zha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a5nyjjekxk02r.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1977927",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732308/",
  "id": "a5nyjjekxk02r",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1977927/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2204|Biosensors and Analytical Detection"
    ]
  ],
  "openalex": "W7223097689",
  "pdf_url": "https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1977927/pdf",
  "pmcid": "PMC13732308",
  "pmid": "42985346",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a5nyjjekxk02r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:12Z",
      "native_id": "10.3389/fmicb.2026.1977927",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1977927/full"
    },
    {
      "first_seen": "2026-11-08T12:22:19Z",
      "native_id": "PMC13732308",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmicb.2026.1977927"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-302X",
      "subfield": "microbiology"
    }
  ],
  "title": "CRISPR diagnostics for maternal–infant HIV, hepatitis B, and syphilis care: clinical roles and translational gaps",
  "title_text": "CRISPR diagnostics for maternal–infant HIV, hepatitis B, and syphilis care: clinical roles and translational gaps",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:19Z",
  "url": "https://research.draconitic.com/paper/a5nyjjekxk02r",
  "venue": "Frontiers in Microbiology",
  "versions": []
}