{
  "abstract": "A single-round affinity/reactivity co-selection of aptamer (ARCaDia), combined with Fast String-Based Clustering (FSBC) analysis of the selection output, identified a compact 10-nucleotide DNA-warhead core motif for streptavidin-selective covalent capture, showing that protein-gated covalent chemistry can arise from a short sequence-dependent placement of a latent warhead in a biotin-sensitive reaction microenvironment. This demonstrates that functional warhead-positioning information is already present after a single selection round.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Engineering Science, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu Tokyo 182-8585 Japan jyang75@wisc.edu taki@pc.uec.ac.jp +81-42-443-5980.",
    "Department of Biological Systems Engineering, Graduate School of Biology-Oriented Science and Technology, KINDAI University, 930 Nishimitani, Kinokawa Wakayama 649-6493 Japan.",
    "Graduate School of Integrated Basic Sciences, Nihon University, Setagaya-ku Tokyo 156-8550 Japan.",
    "School of Medicine and Public Health, University of Wisconsin Madison Wisconsin 53706 USA.",
    "Institute for Advanced Science, UEC Chofu 182-8585 Japan."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chaohui Li",
      "orcid": "0009-0004-4226-2559"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Naoyuki Miyashita"
    },
    {
      "affs": [
        2
      ],
      "name": "Masayasu Kuwahara",
      "orcid": "0000-0002-0810-4627"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jay Yang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Masumi Taki",
      "orcid": "0000-0002-1811-8029"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a5qn51x3wrz37.bib",
  "cited_by": 0,
  "doi": "10.1039/d6cb00303f",
  "fulltext_url": "https://europepmc.org/articles/PMC13673413",
  "id": "a5qn51x3wrz37",
  "issns": [
    "2633-0679"
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  "landing_url": "https://europepmc.org/article/MED/42891161",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
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      "openalex",
      "1605|Click Chemistry and Applications"
    ]
  ],
  "openalex": "W7222666228",
  "pdf_url": "https://europepmc.org/articles/PMC13673413?pdf=render",
  "pmcid": "PMC13673413",
  "pmid": "42891161",
  "published": "2026-10-16",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/a5qn51x3wrz37.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42891161",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42891161"
    },
    {
      "first_seen": "2026-11-07T12:23:32Z",
      "native_id": "PMC13673413",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6cb00303f"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Click Chemistry and Applications",
      "subfield": "organic"
    }
  ],
  "title": "ARCaDia-selected short DNA core positions a latent warhead for protein-gated covalent capture.",
  "title_text": "ARCaDia-selected short DNA core positions a latent warhead for protein-gated covalent capture.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:01Z",
  "url": "https://research.draconitic.com/paper/a5qn51x3wrz37",
  "venue": "RSC chemical biology",
  "versions": []
}