{
  "abstract": "Background: Heart failure with preserved ejection fraction (HFpEF) remains challenging to diagnose, and several scoring systems have been developed to aid evaluation. Emerging evidence suggests that these scores provide prognostic information. This study assessed the prognostic utility of HFpEF scoring systems and compared their performance.\n\nMethods: We analyzed data of 448 consecutive patients with HFpEF from a nationwide, multicenter, prospective, observational heart failure registry (TSOC [Taiwan Society of Cardiology] Heart Failure Registry 2020). We proposed the TSOC‐HFpEF score, which incorporated left ventricular mass index, left atrial volume index, E/e’ ratio, tricuspid regurgitation velocity, and N‐terminal pro‐brain natriuretic peptide level. Its prognostic performance was compared with that of H2FPEF and Heart Failure Association Pre‐test Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, Final Etiology scores.\n\nResults: The mean age of the cohort was 77.0±10.6 years, and 60.7% were women. Mortality rates increased across TSOC‐HFpEF scores, ranging from 0.0 to 23.9 per 100 person‐years. High‐risk categories defined by the Heart Failure Association Pre‐test Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, Final Etiology and TSOC‐HFpEF scores were associated with higher all‐cause mortality than their respective non‐high‐risk categories (hazard ratio [HR], 2.18 [95% CI, 1.17–4.07] and HR, 3.35 [95% CI, 1.97–5.70], respectively), whereas the association for the high‐risk H2FPEF category was of borderline statistical significance (HR, 1.55 [95% CI, 0.99–2.42]; P=0.053). The TSOC‐HFpEF score had the highest discrimination for mortality (C‐index, 0.65) compared with the H2FPEF (C‐index, 0.53) and Heart Failure Association Pre‐test Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, Final Etiology (C‐index, 0.57) scores (P=0.001 and P=0.018, respectively, by DeLong test). Renin‐angiotensin system inhibitor use was associated with lower mortality during a median follow‐up of 2.0 years (interquartile range, 1.5–2.0 years).\n\nConclusions: Diagnostic scores for HFpEF can provide prognostic value. The proposed simple echocardiography and natriuretic peptide‐based scoring systems offered superior risk discrimination.",
  "abstract_shown": true,
  "affiliations": [
    "Heart Center, Cheng Hsin General Hospital Taipei Taiwan",
    "Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan",
    "Division of Cardiology, Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan",
    "Graduate Institute of Biomedical Sciences, MacKay Medical University New Taipei City Taiwan",
    "Department of Medicine MacKay Medical University New Taipei City Taiwan",
    "Division of Cardiology, Department of Internal Medicine MacKay Memorial Hospital New Taipei Taiwan",
    "Division of Cardiovascular Medicine, Department of Medicine China Medical University Hospital Taichung Taiwan",
    "Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan",
    "Taipei Heart Institute, Division of Cardiology, Department of Internal Medicine, School of Medicine College of Medicine, Taipei Medical University Taipei Taiwan",
    "School of Medicine China Medical University Taichung Taiwan",
    "Graduate Institute of Biomedical Sciences, China Medical University Taichung Taiwan",
    "Division of Cardiology Fu Jen Catholic University Hospital New Taipei Taiwan",
    "Department of Cardiology Chang Gung Memorial Hospital, Chang Gung University College of Medicine Taoyuan City Taiwan",
    "Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital Taoyuan City Taiwan",
    "Post‐Baccalaureate Medicine College of Medicine, National Chung Hsing University Taichung Taiwan",
    "Division of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung City Taiwan",
    "Faculty of Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Kaohsiung Taiwan",
    "Division of Cardiology, Department of Internal Medicine Chang Gung University & Chang Gung Memorial Hospital Taoyuan Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Hung‐Yu Chang",
      "orcid": "0000-0003-1219-7739"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Wen‐Hung Huang"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Kuo‐Tzu Sung",
      "orcid": "0000-0001-7032-9731"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Chung‐Wei Cheng"
    },
    {
      "affs": [
        6
      ],
      "name": "Hung‐Pin Wu",
      "orcid": "0000-0002-1009-0586"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Chien‐Yi Hsu"
    },
    {
      "affs": [
        6,
        9,
        10
      ],
      "name": "Kuan‐Cheng Chang",
      "orcid": "0000-0001-6476-9896"
    },
    {
      "affs": [
        11
      ],
      "name": "Chii‐Ming Lee",
      "orcid": "0000-0002-1075-5787"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Pao‐Hsien Chu",
      "orcid": "0000-0003-0361-6348"
    },
    {
      "affs": [
        1,
        14
      ],
      "name": "Jin‐Long Huang",
      "orcid": "0000-0001-6566-5546"
    },
    {
      "affs": [
        15,
        16
      ],
      "name": "Tsung‐Hsien Lin",
      "orcid": "0000-0002-7226-8730"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Chung‐Lieh Hung",
      "orcid": "0000-0002-2858-3493"
    },
    {
      "affs": [
        17
      ],
      "name": "Chun‐Chieh Wang",
      "orcid": "0000-0001-8327-7336"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a6bh0vm54yygq.bib",
  "cited_by": 0,
  "doi": "10.1161/jaha.125.047728",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13744993/",
  "id": "a6bh0vm54yygq",
  "issns": [
    "2047-9980"
  ],
  "landing_url": "https://doi.org/10.1161/jaha.125.047728",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Heart Failure"
    ],
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7212064003",
  "pdf_url": null,
  "pmcid": "PMC13744993",
  "pmid": "42714432",
  "published": "2026-09-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/a6bh0vm54yygq.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T12:22:26Z",
      "native_id": "PMC13744993",
      "source": "pmc",
      "url": "https://doi.org/10.1161/jaha.125.047728"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Comparing the Prognostic Performance Using Various Diagnostic Scoring Systems in Heart Failure With Preserved Ejection Fraction: Insights From the Nationwide Prospective Registry",
  "title_text": "Comparing the Prognostic Performance Using Various Diagnostic Scoring Systems in Heart Failure With Preserved Ejection Fraction: Insights From the Nationwide Prospective Registry",
  "type": "peer-reviewed",
  "updated_at": "2026-11-12T12:21:23Z",
  "url": "https://research.draconitic.com/paper/a6bh0vm54yygq",
  "venue": "Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease",
  "versions": []
}