{
  "abstract": "Tumors exploit immune escape to evade elimination, whereas viruses remodel host immunity to replicate or persist. However, evidence to interpret these processes is fragmented across databases, literature, and omics analyses, hindering gene prioritization. To address this, we developed ImmunEscpMap, a gene-centered knowledgebase connecting cancer and viral-infection evidence within a unified immune-escape framework. The current release contains 55 711 gene-evidence records (53 911 PubMed records from 37 193 unique PMIDs and 1800 Gene Expression Omnibus records across 709 accessions) representing 667 distinct source genes (657 in cancer, 571 in viral infection, and 561 shared). Evidence is organized into eight immune-escape mechanisms and 14 viral contexts, with the cancer branch integrating multi-omics and clinical outcomes, and the viral branch separating mechanistic anchors from infection-associated evidence. The web interface supports identifier search, context browsing, literature views, interactive gene pages, and bulk downloads. ImmunEscpMap is freely available at https://iescpemap.cqmu.edu.cn/, providing a traceable cross-domain map to prioritize candidates and guide follow-up experiments.",
  "abstract_shown": true,
  "affiliations": [
    "School of Artificial Intelligence in Medicine, Chongqing Medical University , Chongqing 400016 ,",
    "Center for Computational Systems Medicine, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 ,",
    "School of Medicine, Shihezi University , Shihezi 832000 ,",
    "Information Center Department, Chongqing Medical University , Chongqing 400016 ,",
    "Bioinformatics and Biomedical Big Data Mining Laboratory, Department of Medical Informatics, School of Big Health, Guizhou Medical University , Guiyang 550025 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shun Jiang",
      "orcid": "0009-0002-0219-6791"
    },
    {
      "affs": [
        1
      ],
      "name": "Shuyue Ma"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuzhou Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhenxing Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiliang Hu"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhiyuan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianguo Wen",
      "orcid": "0000-0002-4846-9030"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiajia Liu",
      "orcid": "0000-0002-0038-9592"
    },
    {
      "affs": [
        4
      ],
      "name": "Jiahao Yi"
    },
    {
      "affs": [
        1
      ],
      "name": "Pora Kim",
      "orcid": "0000-0002-8321-6864"
    },
    {
      "affs": [
        0
      ],
      "name": "Longke Ran",
      "orcid": "0000-0002-6434-5521"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaobo Zhou",
      "orcid": "0000-0001-7191-6495"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a6d57bsw9e6x5.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1013",
  "fulltext_url": null,
  "id": "a6d57bsw9e6x5",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1013/8937186",
  "language": null,
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7222922967",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1013/72085422/gkag1013.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/a6d57bsw9e6x5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1013",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1013/8937186"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "ImmunEscpMap: a gene-centered knowledgebase for immune escape in cancer and viral infection",
  "title_text": "ImmunEscpMap: a gene-centered knowledgebase for immune escape in cancer and viral infection",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/a6d57bsw9e6x5",
  "venue": "Nucleic Acids Research",
  "versions": []
}