{
  "abstract": "Study design\n\nRepeated measures comparative study.Objectives\n\nCompare acute effects of 4 treatment conditions: (i) abdominal binder (Binder), (ii) abdominal functional electrical stimulation (AFES), (iii) AFES and binder (AFES-Binder), and (iv) no intervention (Control), on signs of orthostatic hypotension (OH) and blood pressure (BP) maintenance in individuals with acute and subacute spinal cord injury (SCI).Setting\n\nSpinal injury inpatient ward.Methods\n\nEleven participants with SCI (C3-T5) with at least one sign or symptom of OH underwent a passive sit-up test on 4 days with the 4 treatment conditions. Non-invasive continuous recordings of systolic BP, diastolic BP and calculated mean arterial pressure (MAP) were measured during 4 periods: (1) supine without treatment (5 min); (2) supine with treatment (5 min); (3) upright with treatment (up to 15 min); and (4) supine post-treatment (10 min).Results\n\nLargest drops in BP still resulted in OH in all conditions (p < 0.001), with the largest instantaneous change in MAP in the Binder condition (-41 mmHg [95% CI, -47 to -34]). AFES-Binder condition maintained mean upright MAP relative to supine (-1 mmHg [95% CI, -5 to 2], p = 0.291). Mean upright MAP decreased in all other conditions [Control: (-4 mmHg [95% CI, -7 to -1], p = 0.002); Binder: (-7 mmHg [-10 to -4], p < 0.001); AFES: (-6 mmHg [95% CI, -9 to -2], p < 0.001)]. Mean upright MAP was highest in the AFES-Binder condition.Conclusions\n\nNo single treatment condition prevented OH completely. While AFES with abdominal binder does not eliminate OH, it shows potential to mitigate BP instability during postural transitions in acute and subacute SCI.",
  "abstract_shown": true,
  "affiliations": [
    "University of New South Wales, Sydney, NSW, Australia.",
    "Neuroscience Research Australia, Sydney, NSW, Australia.",
    "The Kolling Institute and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.",
    "Prince of Wales Hospital, Sydney, NSW, Australia.",
    "University of New South Wales, Sydney, NSW, Australia. anne.palermo@sydney.edu.au.",
    "Neuroscience Research Australia, Sydney, NSW, Australia. anne.palermo@sydney.edu.au.",
    "The Kolling Institute and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. anne.palermo@sydney.edu.au.",
    "TIRR, Memorial Hermann, Houston, USA. anne.palermo@sydney.edu.au.",
    "Queen Elizabeth National Spinal Injuries Unit, Queen Elizabeth University Hospital, Glasgow, Scotland, G514TF, UK.",
    "College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, G128QQ, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
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        0,
        1,
        2
      ],
      "name": "Chiettha Prajnadewie"
    },
    {
      "affs": [
        3
      ],
      "name": "Lynn Blecher"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Keith Md McNaughton"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Claire L Boswell-Ruys",
      "orcid": "0000-0003-4922-5262"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Billy L Luu",
      "orcid": "0000-0002-2529-6560"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Harrison T Finn"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Elizabeth A Bye",
      "orcid": "0000-0003-4824-3194"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Bonsan B Lee"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jane E Butler",
      "orcid": "0000-0002-5834-8152"
    },
    {
      "affs": [
        4,
        5,
        6,
        7
      ],
      "name": "Anne E Palermo",
      "orcid": "0000-0003-4642-2594"
    },
    {
      "affs": [
        0,
        1,
        8,
        9
      ],
      "name": "Euan J McCaughey"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a6vy0gzzsm88t.bib",
  "cited_by": 0,
  "doi": "10.1038/s41394-026-00757-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13680490",
  "id": "a6vy0gzzsm88t",
  "issns": [
    "2058-6124"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897136",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Cardiovascular Syncope and Autonomic Disorders"
    ]
  ],
  "openalex": "W7222955407",
  "pdf_url": "https://europepmc.org/articles/PMC13680490?pdf=render",
  "pmcid": "PMC13680490",
  "pmid": "42897136",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a6vy0gzzsm88t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42897136",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897136"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiovascular Syncope and Autonomic Disorders",
      "subfield": "surgery"
    }
  ],
  "title": "Abdominal functional electrical stimulation and binder to reduce orthostatic hypotension in individuals with a subacute spinal cord injury.",
  "title_text": "Abdominal functional electrical stimulation and binder to reduce orthostatic hypotension in individuals with a subacute spinal cord injury.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/a6vy0gzzsm88t",
  "venue": "Spinal cord series and cases",
  "versions": []
}