{
  "abstract": "Diabetes mellitus is associated with metabolic alterations, but amino-acid differences among patients with coronary artery disease (CAD) remain incompletely characterized. We screened 45 amino acids and related metabolites by diabetes status in an exploratory retrospective disease-restricted cohort (recorded diseased-vessel count ≥ 1; n = 33). Argininosuccinic acid was available for 26 patients. Comparisons used exact Wilcoxon tests, Cliff’s delta, and Benjamini–Hochberg correction. Estimated argininosuccinic acid concentrations were higher in diabetes (0.28 [0.21–0.34] vs. 0.15 [0.13–0.19] µmol/L; Cliff’s delta = 0.765; p < 0.001; q = 0.035), the only association surviving false-discovery-rate correction. All argininosuccinic acid estimates were extrapolated below the lowest calibrator and should be interpreted as semiquantitative. The diabetes coefficient remained positive in crude and age- and sex-adjusted HC3-robust models, but renal and influence analyses were imprecise. Argininosuccinic acid correlated inversely with eGFR (rho = −0.445; p = 0.023) and positively with creatinine (rho = 0.486; p = 0.012). The diabetes-by-CAD interaction was not significant (p = 0.183). These data suggest a hypothesis-generating association requiring validation with an appropriate calibration range and careful renal phenotyping.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hypertensiology, Angiology, and Internal Medicine, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznan, Poland.",
    "College of Medicine, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.",
    "College of Medicine, Inje University, 75 Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea.",
    "Centre for Innovative Pharmaceutical Technology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.",
    "Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 61-614 Poznan, Poland.",
    "Thoracic Research Center, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.",
    "Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy.",
    "Department of Cardiac Surgery, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior, 02-507 Warszawa, Poland.",
    "Department of Research, IRCCS ISMETT, 90127 Palermo, Italy.",
    "Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, ½ Długa, 61-848 Poznan, Poland.",
    "Department of Vascular, Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznan, Poland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Beata Krasińska",
      "orcid": "0000-0002-3464-1645"
    },
    {
      "affs": [
        1
      ],
      "name": "Minseung Kang",
      "orcid": "0009-0001-6144-5543"
    },
    {
      "affs": [
        2
      ],
      "name": "Siwon Baek",
      "orcid": "0009-0004-9239-7822"
    },
    {
      "affs": [
        3
      ],
      "name": "Dagmara Pietkiewicz"
    },
    {
      "affs": [
        4
      ],
      "name": "Szymon Plewa",
      "orcid": "0000-0002-9600-3980"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Mariusz Kowalewski",
      "orcid": "0000-0002-5478-3245"
    },
    {
      "affs": [
        6,
        8
      ],
      "name": "Giuseppe Maria Raffa",
      "orcid": "0000-0001-7141-2561"
    },
    {
      "affs": [
        6,
        8
      ],
      "name": "Calogera Pisano"
    },
    {
      "affs": [
        7
      ],
      "name": "Piotr Suwalski"
    },
    {
      "affs": [
        0
      ],
      "name": "Ievgen Spasenenko"
    },
    {
      "affs": [
        0
      ],
      "name": "Katarzyna Gabriel"
    },
    {
      "affs": [
        0
      ],
      "name": "Łukasz Stryczyński",
      "orcid": "0000-0002-8376-7180"
    },
    {
      "affs": [
        9
      ],
      "name": "Anna Olasińska-Wiśniewska",
      "orcid": "0000-0002-4213-8708"
    },
    {
      "affs": [
        4
      ],
      "name": "Jan Matysiak",
      "orcid": "0000-0002-9993-1504"
    },
    {
      "affs": [
        10
      ],
      "name": "Zbigniew Krasiński",
      "orcid": "0000-0002-2798-1959"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrzej Tykarski"
    },
    {
      "affs": [
        5,
        6,
        9
      ],
      "name": "Tomasz Urbanowicz",
      "orcid": "0000-0001-8080-2764"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a6z491k63mpdm.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198766",
  "fulltext_url": "https://europepmc.org/articles/PMC13664958",
  "id": "a6z491k63mpdm",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/19/8766",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Metabolomics and Mass Spectrometry Studies"
    ]
  ],
  "openalex": "W7214967419",
  "pdf_url": "https://europepmc.org/articles/PMC13664958?pdf=render",
  "pmcid": "PMC13664958",
  "pmid": "42884015",
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/a6z491k63mpdm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198766",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8766"
    },
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42884015",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42884015"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Metabolomics and Mass Spectrometry Studies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Serum Argininosuccinic Acid Is Associated with Diabetes in Patients with Coronary Artery Disease: An Exploratory Targeted LC–MS/MS Study",
  "title_text": "Serum Argininosuccinic Acid Is Associated with Diabetes in Patients with Coronary Artery Disease: An Exploratory Targeted LC–MS/MS Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/a6z491k63mpdm",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}