{
  "abstract": "A divergent synthetic strategy to access γ-arylated ketones and α-arylated tetrahydrofurans from readily available homopropargylic alcohols and arene nucleophiles is reported. This method expands the accessible chemical space of γ-arylated ketones via a unique triflic acid-catalyzed hydroalkoxylation/ring-opening arylation sequence proceeding through a 2,3-dihydrofuran intermediate, enabled by the properties of 1,1,1,3,3,3-hexafluoroisopropan-2-ol (HFIP) as solvent. This protocol provides a solution for preparing γ-arylated ketones incorporating sterically hindered arenes, while displaying compatibility with synthetically relevant functionalities to deliver linear and branched γ-arylated ketones, including both aliphatic and aromatic variants. Switching the reaction pathway by employing p-cymene as a hydride donor promotes a reductive hydroalkoxylation, affording α-arylated tetrahydrofurans with high efficiency. Mechanistic studies supported by DFT computations reveal a complex catalytic reaction network in which multiple pathways converge to the observed products.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Claire Miesch"
    },
    {
      "name": "Ewelina Krolicka"
    },
    {
      "name": "Robert J Mayer"
    },
    {
      "name": "David Leboeuf"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a79bdb0b0cktg.bib",
  "cited_by": 1,
  "doi": "10.1039/d6sc03645g",
  "fulltext_url": null,
  "id": "a79bdb0b0cktg",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://hal.science/hal-05743915v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1605|Catalytic Alkyne Reactions"
    ]
  ],
  "openalex": "W7164054078",
  "pdf_url": "https://hal.science/hal-05743915/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-09",
  "publisher": "The Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/a79bdb0b0cktg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "hal-05743915",
      "source": "hal",
      "url": "https://hal.science/hal-05743915v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Alkyne Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Switchable reactivity of homopropargylic alcohols towards γ-arylated ketones and α-arylated tetrahydrofurans in HFIP",
  "title_text": "Switchable reactivity of homopropargylic alcohols towards γ-arylated ketones and α-arylated tetrahydrofurans in HFIP",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/a79bdb0b0cktg",
  "venue": "Chemical Science",
  "versions": []
}