{
  "abstract": "Parabrachial nucleus (PBN) CGRP neurons mediate aversive feeding suppression, but PBN circuitry governing homeostatic, non-aversive feeding suppression remains poorly understood. Here, we identify a circuit in which paraventricular hypothalamus (PVH) neurons innervate BDNF-expressing ventrolateral/dorsolateral PBN (vl/dlPBNBDNF) neurons, which project to multiple hypothalamic nuclei. Refeeding strengthens excitatory and weakens inhibitory synaptic transmission in LPBN-projecting PVH neurons and preferentially induced Bdnf and Fos in vl/dlPBNBDNF neurons compared with elPBNCGRP neurons, whereas noxious LPS preferentially activated elPBNCGRP neurons. Gain- and loss-of-function experiments demonstrated that vl/dlPBNBDNF neurons are sufficient and necessary for feeding suppression without inducing conditioned taste aversion and that this effect require BDNF-TrkB signaling. In addition to hypothalamic inputs, vl/dlPBNBDNF neurons receive dense inputs from major downstream targets of elPBNCGRP neurons. Thus, vl/dlPBNBDNF neurons define a non-aversive feeding-suppression circuit positioned to integrate hypothalamic homeostatic signals with aversive signals, thereby coordinating food intake with internal energy needs and potentially harmful physiological conditions.",
  "abstract_shown": true,
  "affiliations": [
    "University of Florida"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "J. J. An"
    },
    {
      "name": "J.-W. Tan"
    },
    {
      "name": "Y. Chen"
    },
    {
      "name": "X. Yue"
    },
    {
      "affs": [
        0
      ],
      "name": "B. Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a85j0xzx5jrer.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.23.753813",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753813v1.full",
  "id": "a85j0xzx5jrer",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753813v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2807|Regulation of Appetite and Obesity"
    ]
  ],
  "openalex": "W7215043415",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753813v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a85j0xzx5jrer.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:37Z",
      "native_id": "10.64898/2026.09.23.753813",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753813v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "A PVH-to-parabrachial BDNF circuit mediates non-aversive feeding suppression",
  "title_text": "A PVH-to-parabrachial BDNF circuit mediates non-aversive feeding suppression",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:37Z",
  "url": "https://research.draconitic.com/paper/a85j0xzx5jrer",
  "venue": "bioRxiv",
  "versions": []
}