{
  "abstract": "Introduction: Human cytomegalovirus (CMV) is the leading infectious cause of congenital birth defects worldwide. The placenta is a major route of vertical transmission, and both immune and trophoblast cells are susceptible to CMV infection. This study aimed to spatially characterize gene and protein expression changes associated with CMV infection in the human placenta.\n\nMethods: In this exploratory study, CMV+ and control placentae were analyzed using the NanoString GeoMx Digital Spatial Profiler to assess compartment-specific transcriptomic and proteomic profiles in trophoblast and immune cell populations.\n\nResults: CMV+ placentae showed increased immune activation in both trophoblast and immune cells, including pathways related to immune-cell proliferation, differentiation, lymphopoiesis, and T-cell development. Infected placentae also showed altered tissue repair and remodeling pathways, along with changes in proapoptotic proteins and cell death-associated transcripts.\n\nDiscussion: Given the limited sample size, these findings are descriptive and hypothesis-generating. They provide preliminary insight into CMV-associated placental immune dysregulation and identify candidate pathways for investigation in larger, prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States",
    "Mayo Clinic Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States",
    "Department of Pediatrics, Division of Infectious Diseases, University of Miami, Miami, FL, United States",
    "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States",
    "Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, United States",
    "Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, United States",
    "Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, MN, United States",
    "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States",
    "Division of Immunology, Department of Biomedical Sciences, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elise Sintim-Aboagye"
    },
    {
      "affs": [
        1
      ],
      "name": "Huy Quang Quach"
    },
    {
      "affs": [
        2
      ],
      "name": "Indrani Mukherjee"
    },
    {
      "affs": [
        3
      ],
      "name": "Will Sherman"
    },
    {
      "affs": [
        2
      ],
      "name": "Katelyn T. Nguyen"
    },
    {
      "affs": [
        2
      ],
      "name": "Neil Ferland"
    },
    {
      "affs": [
        4
      ],
      "name": "Sheila Farnan"
    },
    {
      "affs": [
        4
      ],
      "name": "Kamila Otrubova"
    },
    {
      "affs": [
        4
      ],
      "name": "Namisha Verma"
    },
    {
      "affs": [
        4
      ],
      "name": "Dawn Littlefield"
    },
    {
      "affs": [
        4
      ],
      "name": "Sohan Punia"
    },
    {
      "affs": [
        5
      ],
      "name": "Erica Johnson"
    },
    {
      "affs": [
        6
      ],
      "name": "Mark Blackstad"
    },
    {
      "affs": [
        6
      ],
      "name": "Mark R. Schleiss"
    },
    {
      "affs": [
        7
      ],
      "name": "Andrew P. Norgan"
    },
    {
      "affs": [
        8
      ],
      "name": "Clive M. Gray"
    },
    {
      "affs": [
        0
      ],
      "name": "Elizabeth Ann L. Enninga"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Rana Chakraborty"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a8cxn1zx9ewb4.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1885923",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696421/",
  "id": "a8cxn1zx9ewb4",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://doi.org/10.3389/fimmu.2026.1885923",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
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      "openalex",
      "2713|Cytomegalovirus and herpesvirus research"
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  "openalex": "W7221516734",
  "pdf_url": "https://europepmc.org/articles/PMC13696421?pdf=render",
  "pmcid": "PMC13696421",
  "pmid": "42936010",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a8cxn1zx9ewb4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cytomegalovirus and herpesvirus research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Spatial analysis of placentae during congenital cytomegalovirus infection suggests distinct cellular profiles in immune and trophoblast cells: an exploratory study",
  "title_text": "Spatial analysis of placentae during congenital cytomegalovirus infection suggests distinct cellular profiles in immune and trophoblast cells: an exploratory study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:45Z",
  "url": "https://research.draconitic.com/paper/a8cxn1zx9ewb4",
  "venue": "Frontiers in Immunology",
  "versions": []
}