{
  "abstract": "Wiskott-Aldrich syndrome (WAS) is a rare X-linked inborn error of immunity characterized by microthrombocytopenia, eczema, and immune dysfunction. In low- and middle-income settings, diagnosis and definitive treatment are often delayed owing to limited access to specialized immunologic assays, genetic testing, and hematopoietic stem cell transplantation. A 4-year-old boy from Ghana had generalized eczematous dermatitis from 4 months of age, with recurrent gum bleeding and intermittent hematochezia. He was admitted with a right upper arm abscess and severe pallor on examination. Testing revealed severe microthrombocytopenia with anemia, elevated IgE with low IgM levels, and T- and B-cell lymphopenia. Whole-genome sequencing identified a pathogenic hemizygous WAS variant (c.1001delG; p.Gly334Valfs*111), confirming classic WAS. He received surgical drainage, blood products, antibiotics, eczema-directed therapy, and secondary antimicrobial prophylaxis. Intravenous immunoglobulin and topical tacrolimus were not used due to cost. This case highlights that recurrent or unusually severe bacterial skin and soft-tissue infections in a boy with eczema, bleeding manifestations, and microthrombocytopenia should prompt consideration of an inborn error of immunity, including WAS. In resource-limited settings, recognizing this triad is critical for prompt microbiological evaluation, targeted antimicrobial therapy, and early initiation of infection-prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana.",
    "Department of Child Health, University of Ghana Medical School, College of Health Sciences, Accra, Ghana."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabrielle Obeng-Koranteng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Joycelyn Assimeng Dame"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Taiba Jibril Afaa"
    },
    {
      "affs": [
        0
      ],
      "name": "Richard Bright Danyoh"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ebenezer Badoe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a8d8v6fbtngpg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.idcr.2026.e02813",
  "fulltext_url": "https://europepmc.org/articles/PMC13744337",
  "id": "a8d8v6fbtngpg",
  "issns": [
    "2214-2509"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999703",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Immunodeficiency and Autoimmune Disorders"
    ]
  ],
  "openalex": "W7223299501",
  "pdf_url": "https://europepmc.org/articles/PMC13744337?pdf=render",
  "pmcid": "PMC13744337",
  "pmid": "42999703",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a8d8v6fbtngpg.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999703",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999703"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunodeficiency and Autoimmune Disorders",
      "subfield": "immunology"
    }
  ],
  "title": "Recurrent bacterial skin infection as a diagnostic clue to Wiskott-Aldrich syndrome in a resource-limited setting: A case report.",
  "title_text": "Recurrent bacterial skin infection as a diagnostic clue to Wiskott-Aldrich syndrome in a resource-limited setting: A case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/a8d8v6fbtngpg",
  "venue": "IDCases",
  "versions": []
}