{
  "abstract": "UBTF tandem duplication (UBTF-TD) is a recently identified genetic abnormality in acute myeloid leukemia (AML) that is associated with a poor prognosis. We report a case of an adult patient with UBTF-TD AML who was refractory to daunorubicin and cytarabine but achieved complete hematological remission following venetoclax and azacitidine (VEN/AZA) therapy. A comparison of the complementary DNA and genomic DNA sequences of UBTF-TD revealed a 60-bp insertion associated with aberrant splicing and partial retention of intron 13. This case provides additional evidence supporting VEN/AZA as a potential therapeutic strategy for UBTF-TD AML and suggests a previously unrecognized association between UBTF-TD and aberrant splicing.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Seigi Oshima"
    },
    {
      "name": "Kazuhisa Chonabayashi"
    },
    {
      "name": "Takashi Sakamoto"
    },
    {
      "name": "Junya Kanda"
    },
    {
      "name": "Yuki Oku"
    },
    {
      "name": "Hiroyuki Matsui"
    },
    {
      "name": "Tadahiko Matsumoto"
    },
    {
      "name": "June Takeda"
    },
    {
      "name": "Chisaki Mizumoto"
    },
    {
      "name": "Kouhei Yamashita"
    },
    {
      "name": "Daichi Inoue"
    },
    {
      "name": "Yasuhito Nannya"
    },
    {
      "name": "Seishi Ogawa"
    },
    {
      "name": "Akifumi Takaori-Kondo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a8g9th6j678az.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.8128-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8128-26/_article",
  "id": "a8g9th6j678az",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8128-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7221812232",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8128-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a8g9th6j678az.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.8128-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8128-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "Response to Venetoclax and Azacitidine in Induction-Refractory Adult Acute Myeloid Leukemia with UBTF Tandem Duplication and Associated Aberrant Splicing: A Case Report",
  "title_text": "Response to Venetoclax and Azacitidine in Induction-Refractory Adult Acute Myeloid Leukemia with UBTF Tandem Duplication and Associated Aberrant Splicing: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/a8g9th6j678az",
  "venue": "Internal Medicine",
  "versions": []
}