{
  "abstract": "Small RNAs represent important carriers of epigenetic information in nematodes, and factors involved in their biogenesis reside within perinuclear germ granules. Among these condensates, Z granules are essential for the inheritance of RNA interference (RNAi). The mechanisms by which Z granules form and promote this process remain unclear. We show that Casein kinase I alpha (KIN-19) is present in Z granules and associated with DEPS-1 and HERD-1 phosphorylation. In the absence of DEPS-1 and HERD-1 phosphorylation, animals have enlarged Z granules and enhanced RNAi inheritance. We propose that DEPS-1 acts as a phosphorylation-regulated scaffold that bridges ZNFX-1 and HERD-1 proteins. Our study demonstrates that Casein kinase I alpha-mediated phosphorylation is an important factor in germ granule modulation and RNAi inheritance, and additionally provides a novel molecular scaffold for understanding germ granule complexity in C. elegans.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Molecular Biology"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "L. Pshanichnaya"
    },
    {
      "name": "M. Brehm"
    },
    {
      "name": "I. Mikicic"
    },
    {
      "name": "S. Hellmann"
    },
    {
      "name": "M. Aaquib"
    },
    {
      "name": "P. Beli"
    },
    {
      "name": "S. Falk"
    },
    {
      "affs": [
        0
      ],
      "name": "R. F. Ketting"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a8y05tb7k0tz7.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.06.756944",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756944v1.full",
  "id": "a8y05tb7k0tz7",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756944v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "1312|RNA Interference and Gene Delivery"
    ]
  ],
  "openalex": "W7220719351",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756944v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a8y05tb7k0tz7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:20Z",
      "native_id": "10.64898/2026.10.06.756944",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756944v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance",
  "title_text": "Phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:43Z",
  "url": "https://research.draconitic.com/paper/a8y05tb7k0tz7",
  "venue": "bioRxiv",
  "versions": []
}