{
  "abstract": "The 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines represent the first comprehensive APHRS guidelines dedicated to the management of atrial fibrillation (AF) and comprise four parts covering epidemiology, detection/screening and integrated care; stroke prevention; rate and rhythm control; and lifestyle risk factor and comorbidity management. Part II focuses on stroke prevention in AF, integrating contemporary global evidence with data and clinical considerations specific to the Asia-Pacific region. It provides evidence-based and practical recommendations for stroke and bleeding risk assessment, oral anticoagulation, selection and appropriate dosing of direct oral anticoagulants, management of patients with special or complex clinical characteristics, and left atrial appendage occlusion. Particular attention is given to issues (and evidence) highly relevant to Asia-Pacific populations, including the evolving risk of ischemic stroke, appropriate anticoagulant dosing, renal function assessment, and balancing thromboembolic and bleeding risks. These recommendations aim to support individualized clinical decision-making, promote appropriate use of stroke-prevention strategies, and improve outcomes for patients with AF across the Asia-Pacific region.",
  "abstract_shown": true,
  "affiliations": [
    "Cardiovascular Center Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei Taiwan.",
    "Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK.",
    "Department of Clinical Medicine Aalborg University Aalborg Denmark.",
    "Department of Cardiology, Lipidology and Internal Medicine With Intensive Coronary Care Unit Medical University of Bialystok Bialystok Poland.",
    "Cardiovascular Department Chang Gung Memorial Hospital Taoyuan Taiwan.",
    "Department of Internal Medicine Seoul National University Hospital Seoul Republic of Korea.",
    "Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea.",
    "Division of Cardiology the First Affiliated Hospital With Nanjing Medical University Nanjing China.",
    "Division of Cardiology, Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea.",
    "Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan.",
    "Division of Cardiology Saiseikai Kumamoto Hospital Kumamoto Japan.",
    "Cardiology Division, Department of Medicine, Queen Mary Hospital The University of Hong Kong Hong Kong SAR China.",
    "Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand.",
    "Centre for Heart Rhythm Disorders Adelaide University Adelaide Australia.",
    "Department of Cardiovascular Medicine Kyorin University School of Medicine Mitaka Tokyo Japan."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tze-Fan Chao",
      "orcid": "0000-0002-6587-3094"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Gregory Y H Lip",
      "orcid": "0000-0002-7566-1626"
    },
    {
      "affs": [
        4
      ],
      "name": "Yi-Hsin Chan",
      "orcid": "0000-0002-1406-8503"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "So-Ryoung Lee",
      "orcid": "0000-0002-6351-5015"
    },
    {
      "affs": [
        7
      ],
      "name": "Mingfang Li"
    },
    {
      "affs": [
        8
      ],
      "name": "Daehoon Kim"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Ling Kuo",
      "orcid": "0000-0002-8604-6151"
    },
    {
      "affs": [
        10
      ],
      "name": "Ken Okumura",
      "orcid": "0000-0002-3202-7203"
    },
    {
      "affs": [
        11
      ],
      "name": "Hung-Fat Tse",
      "orcid": "0000-0002-9578-7808"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Eue-Keun Choi",
      "orcid": "0000-0002-0411-6372"
    },
    {
      "affs": [
        7
      ],
      "name": "Minglong Chen"
    },
    {
      "affs": [
        8
      ],
      "name": "Boyoung Joung",
      "orcid": "0000-0001-9036-7225"
    },
    {
      "affs": [
        12
      ],
      "name": "Rungroj Krittayaphong",
      "orcid": "0000-0001-8684-2361"
    },
    {
      "affs": [
        13
      ],
      "name": "Melissa E Middeldorp",
      "orcid": "0000-0002-4106-9771"
    },
    {
      "affs": [
        14
      ],
      "name": "Kyoko Soejima"
    },
    {
      "affs": [
        8
      ],
      "name": "Hui-Nam Pak",
      "orcid": "0000-0002-3256-3620"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a8yqey7a87aef.bib",
  "cited_by": 0,
  "doi": "10.1002/joa3.70491",
  "fulltext_url": "https://europepmc.org/articles/PMC13687583",
  "id": "a8yqey7a87aef",
  "issns": [
    "1880-4276",
    "1883-2148"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923502",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Atrial Fibrillation Management and Outcomes"
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  "pdf_url": "https://europepmc.org/articles/PMC13687583?pdf=render",
  "pmcid": "PMC13687583",
  "pmid": "42923502",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a8yqey7a87aef.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923502",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923502"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation.",
  "title_text": "2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/a8yqey7a87aef",
  "venue": "Journal of arrhythmia",
  "versions": []
}