{
  "abstract": "Human spaceflight may perturb the gut microbiota, but densely sampled short missions remain poorly characterized. We profiled 27 phase-matched fecal samples from two astronauts during an 18-day International Space Station mission and one ground-based participant following the same daily schedule using Oxford Nanopore full-length 16S sequencing. Participant identity dominated genus-level Bray-Curtis variation (R2 = 0.489, p < 0.001). In astronaut-only community analyses, mission phase explained 23.4% of genus-level (p = 0.035) and 22.3% of species-level (p = 0.021) variation. Astronauts showed greater displacement from personal baselines than B1 (0.331 versus 0.171) and 1.58-fold higher volatility. Astronaut-only taxon models identified 2 of 81 genera and 5 of 139 species; Collinsella increased from quarantine to orbit (coefficient = 2.586, q = 0.037). Thus, the short-duration spaceflight interval was accompanied by individualized, temporally localized community and taxon shifts rather than uniform microbiota restructuring.",
  "abstract_shown": true,
  "affiliations": [
    "Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "G. Gulyas"
    },
    {
      "name": "B. Kakuk"
    },
    {
      "name": "A. Dormo"
    },
    {
      "name": "I. Prazsak"
    },
    {
      "name": "T. Jaray"
    },
    {
      "name": "Z. Csabai"
    },
    {
      "name": "A. T. Schlegl"
    },
    {
      "name": "Z. Boldogkoi"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Tombacz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a95wpjttzxs68.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.01.748461",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748461v1.full",
  "id": "a95wpjttzxs68",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748461v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7205006847",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748461v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a95wpjttzxs68.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:23Z",
      "native_id": "10.64898/2026.09.01.748461",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748461v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Full-length 16S profiling reveals individualized gut microbiota dynamics during short-duration spaceflight",
  "title_text": "Full-length 16S profiling reveals individualized gut microbiota dynamics during short-duration spaceflight",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:23Z",
  "url": "https://research.draconitic.com/paper/a95wpjttzxs68",
  "venue": "bioRxiv",
  "versions": []
}