{
  "abstract": "Mitochondrial division includes contributions from several organelles yet the molecular machinery that facilitates the final Drp1-induced scission of the OMM is largely elusive. We elucidate that FMNL1, a formin family actin assembly factor, is recruited to the mitochondrial division sites through the TGN vesicles in a calcium dependent pathway to complete mitochondrial division. FMNL1 is activated specifically by Cdc42 that generates actin filaments to complete division of the OMM in Drp1 and actin-dependent pathway. Depletion of FMNL1 enhances early events in mitochondrial division pathway characterized by enhanced ER-mitochondrial contacts and increased Drp1 and TGN vesicles on mitochondria which still results in failed mitochondrial division.",
  "abstract_shown": true,
  "affiliations": [
    "Thomas Jefferson University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "B. Tabori"
    },
    {
      "name": "A. Ghosh"
    },
    {
      "name": "M. R. Zavala"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Chakrabarti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a966thmf0fgee.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.21.760700",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1.full",
  "id": "a966thmf0fgee",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7223380297",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a966thmf0fgee.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:19Z",
      "native_id": "10.64898/2026.10.21.760700",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "FMNL1 polymerized actin filaments complete mitochondrial division downstream of Golgi-derived vesicles",
  "title_text": "FMNL1 polymerized actin filaments complete mitochondrial division downstream of Golgi-derived vesicles",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:19Z",
  "url": "https://research.draconitic.com/paper/a966thmf0fgee",
  "venue": "bioRxiv",
  "versions": []
}