{
  "abstract": "Background: Symptom management after proton pump inhibitor (PPI) treatment remains an important issue in gastroesophageal reflux disease (GERD). Objective: To describe symptom distributions during a sequential PPI and Gastrolaryn® Stick management pathway in routine outpatient practice. Methods: In a multicenter, prospective observational survey, 263 GERD patient records were collected at baseline (T0) by 17 gastroenterologists. The intended management sequence comprised 8 weeks of esomeprazole 40 mg daily (T0–T1) followed by 8 weeks of Gastrolaryn® Stick (one stick twice daily; T1–T2). Outcomes included GERD Impact Scale (GIS) response distributions and routine-care characteristics. Analyses were descriptive and based on available records at each survey timepoint. Results: Records were available for 124 patients at T1 (47.1% of baseline) and 112 at T2 (42.6%). Across recorded GIS item responses, the proportion rated “every day” was 12.8%, 0.9%, and 0.3% at T0, T1, and T2, respectively; the corresponding “never” proportions were 24.8%, 44.5%, and 58.4%. These are unpaired, timepoint-specific descriptive summaries and do not establish individual improvement. Investigators submitting records declined from 17 to 11 and 7. Conclusions: Among available records, symptom-frequency distributions were more favorable at later survey timepoints. Substantial missing follow-up, changing site participation, the lack of a comparator and unavailable patient-level paired analyses prevent causal attribution, assessment of relapse prevention, or definitive conclusions about maintenance effectiveness. The survey nevertheless documents management and follow-up patterns encountered in routine practice.",
  "abstract_shown": true,
  "affiliations": [
    "Medicine and Healthcare Science Department, University of Molise, 86100 Campobasso, Italy",
    "Department of Otorhinolaryngology, University Kore, 94100 Enna, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Giorgio Ciprandi",
      "orcid": "0000-0001-7016-8421"
    },
    {
      "affs": [
        1
      ],
      "name": "Ignazio La Mantia",
      "orcid": "0000-0002-7155-273X"
    },
    {
      "affs": [
        0
      ],
      "name": "Attilio Varricchio"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a98a18m60j70g.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218516",
  "fulltext_url": null,
  "id": "a98a18m60j70g",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8516",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/a98a18m60j70g.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218516",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8516"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Gastrolaryn® Stick Following Proton Pump Inhibitor Treatment in Patients with Gastroesophageal Reflux Disease: A Multicenter Real-World Observational Survey",
  "title_text": "Gastrolaryn® Stick Following Proton Pump Inhibitor Treatment in Patients with Gastroesophageal Reflux Disease: A Multicenter Real-World Observational Survey",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/a98a18m60j70g",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}