{
  "abstract": "Background: Sepsis disrupts circadian rhythm, leaving lasting molecular traces and circadian insensitivity to jet lag even after acute phase recovery. However, the core mechanism and biomarkers of residual circadian dysfunction post-sepsis remain unclear, which hinders targeted interventions.\n\nMethods: Male mice were subjected to non-lethal LPS injection, and after 7 days of recovery, liver transcriptomics and plasma metabolomics were integrated. Behavioral, physiological, and molecular analyses were performed, with statistical tests including DESeq2, Student’s t-test, MetaCycle, and ROC curve analysis.\n\nResults: Significant transcriptomic alterations were observed, most prominently at Zeitgeber time 21. Linoleic acid (LA) and alpha-linolenic acid (ALA) were identified as sampling-time-independent candidate biomarkers associated with post-sepsis circadian disruption. Exogenous supplementation of these two fatty acids shortened male mice’s rhythm re-entrainment period.\n\nConclusions: This study identifies a hypothesized Cry1 -essential fatty acid axis potentially contributing to post-sepsis circadian dysfunction based on multi-omics associations, providing novel biomarkers and a metabolic intervention strategy for detecting and treating circadian rhythm disorders in sepsis survivors.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University , ,",
    "National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, The First Affiliated Hospital of Xi’an Jiaotong University , ,",
    "Department of Cell Biology and Physiology, The University of Kansas Medical Center , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junzhou Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianxiao Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Li Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yun Shi"
    },
    {
      "affs": [
        1
      ],
      "name": "Wanni Zou"
    },
    {
      "affs": [
        1
      ],
      "name": "Yunxuan Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Qisheng Su"
    },
    {
      "affs": [
        2
      ],
      "name": "Linlan Qiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Zheng Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Lv"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuanyuan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Rongqian Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a9f2y90rhwnhx.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1916119",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668567/?tool=EBI",
  "id": "a9f2y90rhwnhx",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13668567",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2807|Circadian rhythm and melatonin"
    ]
  ],
  "openalex": "W7215067987",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668567/pdf/?tool=EBI",
  "pmcid": "PMC13668567",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/a9f2y90rhwnhx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13668567",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13668567"
    },
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1916119",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1916119/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
    }
  ],
  "title": "Integrative transcriptomics and metabolomics reveal Cry1-associated hepatic alterations and plasma essential fatty acids as biomarkers of residual circadian disruption post-sepsis",
  "title_text": "Integrative transcriptomics and metabolomics reveal Cry1-associated hepatic alterations and plasma essential fatty acids as biomarkers of residual circadian disruption post-sepsis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/a9f2y90rhwnhx",
  "venue": "Frontiers in endocrinology",
  "versions": []
}