{
  "abstract": "Background: Emerging evidence suggests that glyoxalase 1 (Glo-1) may contribute to sex-specific phenotypes in schizophrenia. This study aims to investigate the sex-specific effects of Glo-1 polymorphisms on schizophrenia susceptibility.\n\nMethods: Four Glo-1 genetic polymorphisms were genotyped using SNaPshot technology in a sample of 1214 schizophrenic patients and 1138 age- and sex-matched healthy controls.\n\nResults: Significant associations were found between schizophrenia and control groups in both genotypic [P = 0.044, false discovery rate (FDR) correction] and allelic (P = 0.036, FDR correction) distributions of the rs1781735 polymorphism, whereas no significant difference for rs9470916, rs4746, or rs1130534 (P > 0.05). Haplotype analysis for the rs9470916-rs1130534-rs4746-rs1781735 haplotype revealed significant associations with schizophrenia, particularly for the C-T-A-G haplotype, which was less frequent in schizophrenic patients than controls [odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75–0.98, P = 0.024]. In sex-stratified analyses, significant associations in females were observed for rs1781735 (P = 0.020 for genotype, P = 0.004 for allele, FDR correction), rs1130534 (P = 0.037 for genotype, P = 0.011 for allele, FDR correction), and rs9470916 (P = 0.020 for genotype, P = 0.004 for allele, FDR correction). Furthermore, haplotype analysis identified female-specific associations for the C-T-A-G (OR = 0.73, 95% CI = 0.59–0.91, P = 0.005) and A-A-A-T (OR = 1.38, 95% CI = 1.08–1.75, P = 0.009) haplotypes, whereas no associations were detected in the male subgroup.\n\nConclusions: Single-nucleotide polymorphisms in Glo-1 exhibited a female-specific association with schizophrenia in a Han Chinese cohort, suggesting a potential sex-specific role of Glo-1 in schizophrenia susceptibility.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry",
    "Affiliated Hospital of Guangdong Medical University, Zhanjiang",
    "Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan",
    "Institute of Neurology",
    "Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amy Jing-Wen Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei-Wei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenge Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xudong Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Susu Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Kangdu Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhun Dai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yusheng Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhixiong Lin"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Guoda Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Dong Lv"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a9pvcwgd650pq.bib",
  "cited_by": 0,
  "doi": "10.1097/ypg.0000000000000425",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13718894/",
  "id": "a9pvcwgd650pq",
  "issns": [
    "0955-8829",
    "1473-5873"
  ],
  "landing_url": "https://doi.org/10.1097/ypg.0000000000000425",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ],
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
    ]
  ],
  "openalex": "W7215038046",
  "pdf_url": null,
  "pmcid": "PMC13718894",
  "pmid": "42820377",
  "published": "2026-10-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a9pvcwgd650pq.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:50Z",
      "native_id": "PMC13718894",
      "source": "pmc",
      "url": "https://doi.org/10.1097/ypg.0000000000000425"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Female-specific associations of glyoxalase 1 polymorphisms with schizophrenia in a Han Chinese case–control study",
  "title_text": "Female-specific associations of glyoxalase 1 polymorphisms with schizophrenia in a Han Chinese case–control study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:50Z",
  "url": "https://research.draconitic.com/paper/a9pvcwgd650pq",
  "venue": "Psychiatric Genetics",
  "versions": []
}