{
  "abstract": "Endothelial dysfunction is a fundamental catalyst of atherosclerosis and cardiovascular mortality in type 2 diabetes mellitus (T2DM). While sodium-glucose co-transporter 2 inhibitors (SGLT2is) provide robust cardioprotection, whether these benefits stem from direct vasculature effects or from secondary systemic hemodynamics remains an active translational frontier. At the cellular level, preclinical data suggests that SGLT2is may modulate homeostatic pathways by suppressing NADPH oxidase-mediated oxidative stress, attenuating NF-κB/NLRP3-driven inflammatory cascades, and preserving endothelial nitric oxide synthase (eNOS) activity. In clinical cohorts, these molecular actions correlate with heterogeneous changes in flow-mediated dilation (FMD) and reductions in arterial stiffness. However, translating these cellular findings to macrovascular outcomes is highly confounded by concurrent volume contraction, blood pressure lowering and metabolic shifts.",
  "abstract_shown": true,
  "affiliations": [
    "Grupo de Investigación en Enfermedades Cardiorrenales y Metabólicas, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/Santiago Ramón y Cajal S/N, 46115 Valencia, Spain"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Owahabanun-Joshua Okojie",
      "orcid": "0009-0001-6805-7738"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Checa-Ros",
      "orcid": "0000-0001-8958-6711"
    },
    {
      "affs": [
        0
      ],
      "name": "Luis D’Marco",
      "orcid": "0000-0003-0148-891X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a9td50tvaagn6.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16110824",
  "fulltext_url": null,
  "id": "a9td50tvaagn6",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/11/824",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes Treatment and Management"
    ]
  ],
  "openalex": "W7224095789",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/a9td50tvaagn6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16110824",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/11/824"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes Treatment and Management",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "SGLT2 Inhibitors as Endothelial Protectors: Mechanisms of Vascular Restoration in Type 2 Diabetes",
  "title_text": "SGLT2 Inhibitors as Endothelial Protectors: Mechanisms of Vascular Restoration in Type 2 Diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/a9td50tvaagn6",
  "venue": "Metabolites",
  "versions": []
}