{
  "abstract": "Introduction: Sickle cell disease (SCD) is associated with high premature mortality and remains an important public health challenge. Advances in disease management, access to specialized care, and implementation of public health policies have contributed to improved outcomes over the last years. Objectives: This study aims to describe age at death among patients with SCD in Brazil and to assess temporal trends by sex and disease severity. Materials and Methods: Data were obtained from the Mortality Information System (SIM/DATASUS) and included deaths with SCD (ICD-10 codes D57.0 and D57.1) as the underlying cause from 2013 to 2024. Age at death was described overall and by sex and disease severity (with or without crisis). Temporal trends were assessed by sex and disease severity using linear and joinpoint regression. Results: A total of 5,355 patients were included. The overall mean age at death was 32.90-years (SD: 19.77). Over time, age at death increased by 1.22% according to the Annual Percent Change (APC) (95% CI: 0.22 to 2.20; p=0.02). Females (n=2,646) had mean age at death of 35.05-years (SD: 20.48), with an APC of 1.28% (95% CI: 0.30 to 2.23; p=0.01). Males (n=2,709) had a mean age at death of 30.79 years (SD: 18.83), with an APC of 1.12% (95% CI: -0.03 to 2.20; p=0.06). In the linear regression analysis, males had, on average, a 4.29-year lower age at death than females (p<0.01). Individuals with SCD with crisis (n=1,506) had a mean age at death of 29.49 years (SD: 18.59), with an APC of 1.31% (95% CI: -0.37 to 3.02; p=0.13). Among those without crises (n=3,849), the mean age at death was 34.23 years (SD: 20.06), with an APC of 1.57% (95% CI: 0.73 to 2.39; p<0.01). In the linear regression analysis, patients with crisis had, on average, a 5.19-year lower age at death than those without crisis (p<0.01). Discussion: The findings suggest an overall increase in age at death among individuals with SCD in Brazil over the study period, although this trend was not consistently observed across all subgroups. Males and patients with SCD with crisis presented lower ages at death, which may reflect differences in treatment access, healthcare utilization, and other clinical determinants. Conclusion: These findings highlight disparities by sex and disease severity, with lower ages at death among males and patients with crisis. The overall upward pattern may reflect improvements in care, disease management, and public health policies for SCD in Brazil.",
  "abstract_shown": true,
  "affiliations": [
    "IQVIA, São Paulo, SP, Brazil"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Júlia Souza OLIVEIRA"
    },
    {
      "affs": [
        0
      ],
      "name": "Isabel Cristina Gomes MOURA"
    },
    {
      "affs": [
        0
      ],
      "name": "Leonardo Mattos GALHARDO"
    },
    {
      "affs": [
        0
      ],
      "name": "Gustavo Pires MATHEUS"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a9wfhj9fp0vf6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.htct.2026.106669",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2531137926004165",
  "id": "a9wfhj9fp0vf6",
  "issns": [
    "2531-1379",
    "2531-1387"
  ],
  "landing_url": "https://doi.org/10.1016/j.htct.2026.106669",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC633-647.5"
    ],
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7223157757",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2531137926004165/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/a9wfhj9fp0vf6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:22Z",
      "native_id": "fb0f1d62d9d843c89664d2422219b296",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.htct.2026.106669"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "LONGITUDINAL TRENDS IN MORTALITY AGE AMONG PATIENTS WITH SICKLE CELL DISEASE: REAL-WORD DATA (2013‒2024)",
  "title_text": "LONGITUDINAL TRENDS IN MORTALITY AGE AMONG PATIENTS WITH SICKLE CELL DISEASE: REAL-WORD DATA (2013‒2024)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:22Z",
  "url": "https://research.draconitic.com/paper/a9wfhj9fp0vf6",
  "venue": "Hematology, Transfusion and Cell Therapy",
  "versions": []
}