{
  "abstract": "Nanomaterial-based antibacterial therapy presents an alternative solution to antibiotic resistance. However, most research focuses on enhancing antibacterial activity while neglecting the selectivity of nanomaterials, leading to indiscriminate damage to mammalian cells. Here, we design a synergistic boron nitride-polydopamine@MOF-199 nanocomposite (BPM NC) that interferes with bacterial binary fission. Its selectivity stems from suppressing FtsZ polymerization during bacterial division, while its high efficiency arises from synergistic mechanisms such as disrupting membrane potential and bacterial defense systems. These effects induce molecular-level disruptions in bacterial biological processes, enabling BPM NC (0.35 μg/mL) to rapidly inactivate bacteria (10 ⁷ CFU/mL) in 30 min—358-fold enhancement over its precursor h-BN. In burn infection models, BPM NC exhibits significant efficacy in male mice and female pigs, outperforming the clinical drug silver sulfadiazine. This work provides a promising insight into developing antibacterial nanomaterials that combine selectivity and high activity, offering a strategy for next-generation antibacterial therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Hao Liu"
    },
    {
      "name": "Zhixuan Yu"
    },
    {
      "name": "Ling Yang"
    },
    {
      "name": "Siyang Zhao"
    },
    {
      "name": "Tianzhi Li"
    },
    {
      "name": "Rui Li"
    },
    {
      "name": "Guanyu Ding"
    },
    {
      "name": "Ling Liu",
      "orcid": "0000-0001-7912-568X"
    },
    {
      "name": "Shaojun Dong",
      "orcid": "0000-0002-0263-6577"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a9zqbvyphsyh1.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-79027-1",
  "fulltext_url": null,
  "id": "a9zqbvyphsyh1",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-79027-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/a9zqbvyphsyh1.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:29Z",
      "native_id": "10.1038/s41467-026-79027-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-79027-1"
    }
  ],
  "subjects": [],
  "title": "A nanocomposite-mediated synergistic division inhibition strategy for selective antibacterial therapy against burn infections",
  "title_text": "A nanocomposite-mediated synergistic division inhibition strategy for selective antibacterial therapy against burn infections",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T00:20:14Z",
  "url": "https://research.draconitic.com/paper/a9zqbvyphsyh1",
  "venue": "Nature Communications",
  "versions": []
}