{
  "abstract": "Genetic variations are involved in determining heart failure (HF) phenotypes. While variants within the BAG3 gene have been associated with HF in European populations, the impact of specific single nucleotide polymorphisms (SNPs) within the BAG3 gene in determining phenotypes of HF with preserved ejection fraction (HFpEF) in Southeast Asian populations is unknown. Therefore, in this study, we identified BAG3 SNPs and investigated their biological and clinical relevance in determining HFpEF phenotypes among an Indonesian HFpEF cohort. We conducted a study involving 36 patients with HFpEF and 30 healthy individuals. We detected the presence of rs196326 and rs2240777 SNPs in our cohort. However, the rs2234962 polymorphism, which has been associated with HF and cardiomyopathy in Western populations, was absent in our Indonesian cohort. We found that the rs196326 SNP was significantly associated with relative wall thickness (RWT), with patients carrying the CG genotype displayed significantly lower RWT. Additionally, the rs196326 CG/GG genotypes were correlated with higher serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and lower Caspase-3 levels. Our study showed that the BAG3 rs196326 polymorphism was significantly associated with HFpEF phenotypes in the Indonesian population. This highlights the importance of identifying population-specific as genetic markers of disease severity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia",
    "Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia",
    "Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia",
    "Cardiovascular and Cardiometabolic Science Research Group, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia",
    "Department of Cardiology and Vascular Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia",
    "Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia",
    "Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Citrawati Dyah Kencono Wungu",
      "orcid": "0000-0001-5180-957X"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Hendri Susilo"
    },
    {
      "affs": [
        5
      ],
      "name": "Jesselyn Wijaya"
    },
    {
      "affs": [
        5
      ],
      "name": "Cleodylon R. Susanto",
      "orcid": "0009-0008-0858-1117"
    },
    {
      "affs": [
        5
      ],
      "name": "Kevin Kevin"
    },
    {
      "affs": [
        2
      ],
      "name": "David Nugraha",
      "orcid": "0000-0001-9194-2738"
    },
    {
      "affs": [
        6
      ],
      "name": "Delvac Oceandy",
      "orcid": "0000-0002-6242-6491"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aab1my69cv3fp.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0361206",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730335/",
  "id": "aab1my69cv3fp",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0361206",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Alleles"
    ],
    [
      "heading",
      "Apoptosis"
    ],
    [
      "heading",
      "Biochemistry"
    ],
    [
      "heading",
      "Biology and Life Sciences"
    ],
    [
      "heading",
      "Cardiology"
    ],
    [
      "heading",
      "Cell Biology"
    ],
    [
      "heading",
      "Cell Death"
    ],
    [
      "heading",
      "Cell Processes"
    ],
    [
      "heading",
      "Cholesterol"
    ],
    [
      "heading",
      "Ejection Fraction"
    ],
    [
      "heading",
      "Evolutionary Biology"
    ],
    [
      "heading",
      "Genetic Loci"
    ],
    [
      "heading",
      "Genetic Mapping"
    ],
    [
      "heading",
      "Genetic Polymorphism"
    ],
    [
      "heading",
      "Genetics"
    ],
    [
      "heading",
      "Heart Failure"
    ],
    [
      "heading",
      "Heredity"
    ],
    [
      "heading",
      "Lipids"
    ],
    [
      "heading",
      "Medicine and Health Sciences"
    ],
    [
      "heading",
      "Population Biology"
    ],
    [
      "heading",
      "Population Genetics"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "heading",
      "Single Nucleotide Polymorphisms"
    ],
    [
      "heading",
      "Variant Genotypes"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Lipids/Cholesterol"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cell processes/Cell death/Apoptosis"
    ],
    [
      "plos",
      "/Biology and life sciences/Evolutionary biology/Population genetics/Genetic polymorphism"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Genetic loci/Alleles"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Heredity/Genetic mapping/Variant genotypes"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Population genetics/Genetic polymorphism"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Single nucleotide polymorphisms"
    ],
    [
      "plos",
      "/Biology and life sciences/Population biology/Population genetics/Genetic polymorphism"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Ejection fraction"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Heart failure"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": "PMC13730335",
  "pmid": "42976148",
  "published": "2026-11-03",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/aab1my69cv3fp.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:20:43Z",
      "native_id": "10.1371/journal.pone.0361206",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0361206"
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    {
      "first_seen": "2026-11-07T12:22:55Z",
      "native_id": "PMC13730335",
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  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Biochemistry",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "heading:Cell Biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "heading:Evolutionary Biology",
      "subfield": "evolutionary-biology"
    },
    {
      "field": "biology",
      "origin": "plos:genetics",
      "subfield": "genetics-genomics"
    },
    {
      "field": "medicine",
      "origin": "plos:cardiology",
      "subfield": "cardiovascular"
    }
  ],
  "title": "BAG3 genetic variant is associated with heart failure with preserved ejection fraction phenotypes",
  "title_text": "BAG3 genetic variant is associated with heart failure with preserved ejection fraction phenotypes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:55Z",
  "url": "https://research.draconitic.com/paper/aab1my69cv3fp",
  "venue": "PLOS One",
  "versions": []
}