{
  "abstract": "Background: Despite the fact that immunotherapy is reshaping the therapeutic landscape of bladder cancer, immune evasion remains a major obstacle to durable clinical benefit. Therefore, elucidating the mechanisms underlying immune resistance is essential for developing novel therapeutic strategies.\n\nMethods: In this study, we performed a genome-wide CRISPR-Cas9 screen in bladder cancer cells co-cultured with CD8+ T cells and identified the SLP adaptor and CSK-interacting membrane protein (SCIMP) as a key gene that enhances CD8+ T cell antitumor immunity.\n\nResults: SCIMP serves as a favorable prognostic biomarker in patients with bladder cancer treated with immunotherapy. Mechanistically, SCIMP restricts JAK1 phosphorylation in an adaptor-independent manner, suppressing the IFN-γ/JAK1/STAT5A/PD-L1 signaling axis. Meanwhile, YTHDF2 destabilizes the m6A-tagged SCIMP transcripts to reduce their expression. Remarkably, SCIMP synergizes with PD-1 blockade in suppressing tumor growth.\n\nConclusions: Collectively, these findings reveal a previously unexplored non-canonical role of SCIMP in preventing immune evasion and provide a potential therapeutic target for bladder cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China",
    "Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Huazhong University of Science and Technology, Wuhan, Hubei, China",
    "Department of Urology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China",
    "Institute of Urologic Science and Technology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yongqiang You",
      "orcid": "0000-0003-1316-3768"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hui Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayin Sun"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yujun Shuai"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Ye Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Sijia Hong"
    },
    {
      "affs": [
        0
      ],
      "name": "Ning Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Miao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Guosong Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aagpfjvwx232e.bib",
  "cited_by": 0,
  "doi": "10.1136/jitc-2026-015651",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723913/",
  "id": "aagpfjvwx232e",
  "issns": [
    "2051-1426"
  ],
  "landing_url": "https://doi.org/10.1136/jitc-2026-015651",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "1506"
    ],
    [
      "heading",
      "Basic and Translational Cancer Immunology"
    ],
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7223980514",
  "pdf_url": null,
  "pmcid": "PMC13723913",
  "pmid": "42946393",
  "published": "2026-10-27",
  "publisher": "BMJ Publishing Group",
  "ris": "https://research.draconitic.com/paper/aagpfjvwx232e.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:28Z",
      "native_id": "PMC13723913",
      "source": "pmc",
      "url": "https://doi.org/10.1136/jitc-2026-015651"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Non-canonical function of SCIMP restricts JAK1 activity to counteract immune evasion in bladder cancer",
  "title_text": "Non-canonical function of SCIMP restricts JAK1 activity to counteract immune evasion in bladder cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:38Z",
  "url": "https://research.draconitic.com/paper/aagpfjvwx232e",
  "venue": "Journal for Immunotherapy of Cancer",
  "versions": []
}