{
  "abstract": "To evaluate the efficacy of unrelated allogeneic hematopoietic stem cell transplantation (URD-HSCT) in severe aplastic anemia (SAA), this study retrospectively analyzed the clinical data of 206 patients at a single center. The median age was 28 years (range: 5-64 years), and 13.6% had received immunosuppressive therapy prior to transplantation. The median time to neutrophil and platelet engraftment was 12 days (range: 9-22 days / 8-55 days), respectively, with a graft failure rate of 3.4%. The cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD) was 21.7% (95% CI: 16.6%-27.8%), and that of chronic GVHD was 20.4% (95% CI: 15.4%-26.6%). Survival analysis revealed a 7-year overall survival (OS) rate of 91% for the entire cohort. Notably, the 7-year OS rate was significantly higher in the donor age ≤30 years group compared to the >30 years group (97% vs 85%, P = 0.0028), and in the HLA 10/10 matched group compared to the 9/10 matched group (95% vs 86%, P = 0.023). Multivariate analysis identified donor age >30 years, and HLA 9/10 matching as independent risk factors for OS and graft-versus-host disease-free, relapse-free survival (GRFS). URD-HSCT is an effective treatment for SAA, and selecting an appropriate donor can improve treatment outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China; Department of Hematology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinrong Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Liangliang Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaowei Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjian Mo"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruiqing Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yumiao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Caixia Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shilin Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shiyi Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingfen Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuping Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shunqing Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aav6dyw2sga2m.bib",
  "cited_by": 0,
  "doi": "10.7150/ijms.137416",
  "fulltext_url": "https://europepmc.org/articles/PMC13685043",
  "id": "aav6dyw2sga2m",
  "issns": [
    "1449-1907"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910131",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7214631777",
  "pdf_url": "https://europepmc.org/articles/PMC13685043?pdf=render",
  "pmcid": "PMC13685043",
  "pmid": "42910131",
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aav6dyw2sga2m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910131",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910131"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Hematopoietic Stem Cell Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Efficacy of Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia: A Single-Center Retrospective Study.",
  "title_text": "Efficacy of Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia: A Single-Center Retrospective Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/aav6dyw2sga2m",
  "venue": "International journal of medical sciences",
  "versions": []
}