{
  "abstract": "Background\n\nDedifferentiated liposarcoma (DDLPS), a rare disease with limited research, exhibits resistance to radiotherapy and chemotherapy. Few reports have analyzed the tumor microenvironment of retroperitoneal undifferentiated liposarcoma using single-cell sequencing.Methods\n\nSingle-cell analysis of three retroperitoneal DDLPS cases characterized the cellular and immune microenvironment.Results\n\nOur findings reveal significant heterogeneity among malignant cells in DDLPS, with chromosome 6 deletions being prevalent across malignant cell subpopulations and potentially linked to reduced immunogenicity based on pathway analyses. Notably, the coexistence of CD8 + T cell exhaustion and cytotoxicity reflects a continuum of exhaustion transition. Moreover, we identify a C3 + malignant cell subpopulation with ECM remodeling, angiogenesis, and activated complement pathway. Further exploration suggested that C3 + malignant cells may recruit IL2RA+ regulatory T cells and SPP1 + macrophages through the C3-C3aR1 axis.Conclusion\n\nOur findings provide new insights into the application of immunotherapy in sarcoma.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
    "Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
    "Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
    "Day Surgery Operating Room, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
    "Department of Retroperitoneal Tumor Surgery, Peking University People's Hospital, Beijing, 100044, China. xiaomengmeng@pku.edu.cn.",
    "Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. hujunhong@zzu.edu.cn.",
    "Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn.",
    "Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Shengyun Hu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yatong Dang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Baojing Tuo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Senbo Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiyong Zhang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Lin Gan"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaoqing Gao"
    },
    {
      "affs": [
        4
      ],
      "name": "Mengmeng Xiao"
    },
    {
      "affs": [
        5
      ],
      "name": "Junhong Hu"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Zhenqiang Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ab76grjnk6ms3.bib",
  "cited_by": 0,
  "doi": "10.1186/s12885-026-16750-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13695301",
  "id": "ab76grjnk6ms3",
  "issns": [
    "1471-2407"
  ],
  "landing_url": "https://europepmc.org/article/MED/42926214",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2740|Sarcoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7202379463",
  "pdf_url": "https://europepmc.org/articles/PMC13695301?pdf=render",
  "pmcid": "PMC13695301",
  "pmid": "42926214",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/ab76grjnk6ms3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42926214",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42926214"
    },
    {
      "first_seen": "2026-10-30T13:46:03Z",
      "native_id": "929e3caa8af247cbb49be3b3e469be5f",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12885-026-16750-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "Single-cell analysis reveals the potential immunoregulatory role of C3 + malignant cell subpopulations in dedifferentiated liposarcoma.",
  "title_text": "Single-cell analysis reveals the potential immunoregulatory role of C3 + malignant cell subpopulations in dedifferentiated liposarcoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:03Z",
  "url": "https://research.draconitic.com/paper/ab76grjnk6ms3",
  "venue": "BMC cancer",
  "versions": []
}