{
  "abstract": "Extracellular vesicles (EVs) are emerging cell-free therapeutic platforms for cutaneous wound repair that regulate diverse cellular processes, including intercellular communication, inflammation, angiogenesis, extracellular matrix remodeling, and tissue repair. Recent advances in parental cell preconditioning, EV engineering, smart EV design, and biomaterial-assisted delivery have further enhanced the therapeutic potential of EV-based approaches. These advances have stimulated growing interest in applying EVs to skin wound repair, where EVs act on resident skin cells and immune cells to promote regenerative healing. In particular, macrophage reprogramming is well characterized, whereas EV-mediated regulation of other immune-cell populations remains less clearly defined. Standardized EV production, reliable potency assays, and dynamic in vivo approaches will be essential for defining how EVs coordinate regenerative and immune-regulatory processes. This review discusses EV-mediated cutaneous wound repair with emphasis on temporal and cell-specific immune remodeling, regenerative mechanisms, and translational challenges.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic Surgery, Ulsan Medical Center",
    "Cellexobio, Ltd.",
    "Institute for Quantitative Health Science and Engineering (IQ), Michigan State University",
    "Department of Orthopedic Surgery, Yeungnam University College of Medicine",
    "Laboratory of Veterinary Tissue Engineering, College of Veterinary Medicine, Kyungpook National University",
    "Department of Medicine, College of Human Medicine, Michigan State University",
    "Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Gun Woo Lee"
    },
    {
      "affs": [
        3
      ],
      "name": "Wook-Tae Park"
    },
    {
      "affs": [
        4
      ],
      "name": "Min-Soo Seo"
    },
    {
      "affs": [
        2,
        5,
        6
      ],
      "name": "Sangbum Park"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ace1188pj1mwd.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1938968",
  "fulltext_url": "https://europepmc.org/articles/PMC13682443",
  "id": "ace1188pj1mwd",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1938968/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7220742180",
  "pdf_url": "https://europepmc.org/articles/PMC13682443?pdf=render",
  "pmcid": "PMC13682443",
  "pmid": "42903835",
  "published": "2026-10-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ace1188pj1mwd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1938968",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1938968/full"
    },
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903835",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903835"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Extracellular vesicle-mediated immune remodeling in cutaneous wound repair",
  "title_text": "Extracellular vesicle-mediated immune remodeling in cutaneous wound repair",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/ace1188pj1mwd",
  "venue": "Frontiers in Immunology",
  "versions": []
}