{
  "abstract": "Neurons could offset the conductance load imposed by their dendrites through channel expression (compensation), or channel expression could move with that load (reinforcement); which arrangement holds in adult cortex is unknown. Writing rheobase as the product of input conductance and an effective-voltage factor turns the question into a sign test. In mouse cortical GABAergic Patch-seq neurons, after removal of transcriptomic type and covariates, an out-of-fold channel-gene score co-varies positively with residual input conductance (median Spearman {rho} = 0.32 over 20 cross-fitting splits, n = 493) and with a conductance score predicted from dendritic morphology alone ({rho} = 0.23, n = 483). The association is carried mainly by Sst and Pvalb cells and is close to zero in Vip cells. Its slope on the compensation axis is 0.13, against -1 for compensation and 0 for independence, so the finding concerns direction rather than magnitude: it excludes a population-wide compensation rule without implying strong amplification. Reduced NEURON models show that a compensatory correction is biophysically feasible, and the morphology-derived conductance predictor transfers from mouse to human reconstructions ({rho} = 0.27, n = 128).",
  "abstract_shown": true,
  "affiliations": [
    "University of Picardie Jules Verne"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "G. Cirrincione"
    },
    {
      "affs": [
        0
      ],
      "name": "F. Grassia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ache549rbn9zd.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.11.765852",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1.full",
  "id": "ache549rbn9zd",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ache549rbn9zd.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:22:59Z",
      "native_id": "10.64898/2026.11.11.765852",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Channel expression aligns with dendritic conductance load in the reinforcing, not compensatory, direction in cortical GABAergic neurons",
  "title_text": "Channel expression aligns with dendritic conductance load in the reinforcing, not compensatory, direction in cortical GABAergic neurons",
  "type": "preprint",
  "updated_at": "2026-11-14T00:20:42Z",
  "url": "https://research.draconitic.com/paper/ache549rbn9zd",
  "venue": "bioRxiv",
  "versions": []
}