{
  "abstract": "Vitiligo is an immune-mediated disease characterized by depigmentation of the skin. Although transcriptomic studies have advanced the mechanistic understanding of the disease, comprehensive proteomic characterization of vitiligo-affected skin is lacking. This study aimed to investigate proteomic alterations in non-segmental vitiligo. Punch biopsies (2 mm) were collected from lesional (n = 10), perilesional (n = 62), and non-lesional skin (n = 62) from patients with vitiligo and from demographically matched (age, sex, and anatomical site) healthy controls (n = 12). Proteomic profiling was performed using mass spectrometry, and the data were analyzed in pairwise comparisons. The proteomic analyses quantified a total of 4556 proteins, including 40 differentially expressed proteins (false discovery rate <0.05). The comparison between lesional and healthy skin revealed the highest number of differentially expressed proteins, which were predominantly associated with inflammatory and immune-related processes, including TNF-α signaling, complement pathways, and signal transducer and activator of transcription 6 signaling. The comparison between lesional and non-lesional skin showed differences in protein quantification related to melanocyte differentiation and keratinocyte stress responses. These proteins included protein O-fucosyltransferase 1, which is involved in melanocyte development via Notch-1 signaling, and keratin 6B, which is implicated in keratinocyte migration during wound repair. This study provides insights into vitiligo pathophysiology, identifying proteins that, to our knowledge, have not previously been associated with vitiligo.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte Hospital, Hellerup, Denmark.",
    "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
    "Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.",
    "The Leo Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.",
    "Novo Nordisk Foundation Center for Protein Research, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.",
    "Department of Pathology, Hospital of Southern Jutland, Aabenraa, Denmark.",
    "Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.",
    "Department of Pathology, Zealand University Hospital, Næstved, Denmark.",
    "Department of Dermatology, Mass General Brigham, Harvard Medical School, Cambridge, Massachusetts, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Morten Bahrt Haulrig"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Marianne B Løvendorf"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Sonja Kabatnik"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Bjørn Kromann"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Ann Mari Rosager"
    },
    {
      "affs": [
        7
      ],
      "name": "Michael Bzorek"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lone Skov"
    },
    {
      "affs": [
        1,
        2,
        3,
        4,
        8
      ],
      "name": "Beatrice Dyring-Andersen",
      "orcid": "0000-0002-3012-2645"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/acmhqht49q0vw.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjidi.2026.100533",
  "fulltext_url": "https://europepmc.org/articles/PMC13694994",
  "id": "acmhqht49q0vw",
  "issns": [
    "2667-0267"
  ],
  "landing_url": "https://europepmc.org/article/MED/42926901",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|melanin and skin pigmentation"
    ]
  ],
  "openalex": "W7212053952",
  "pdf_url": "https://europepmc.org/articles/PMC13694994?pdf=render",
  "pmcid": "PMC13694994",
  "pmid": "42926901",
  "published": "2026-09-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/acmhqht49q0vw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42926901",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42926901"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|melanin and skin pigmentation",
      "subfield": "cell-biology"
    }
  ],
  "title": "Proteomic analysis of non-segmental vitiligo identifies immune- and keratinocyte-associated protein alterations.",
  "title_text": "Proteomic analysis of non-segmental vitiligo identifies immune- and keratinocyte-associated protein alterations.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/acmhqht49q0vw",
  "venue": "JID innovations : skin science from molecules to population health",
  "versions": []
}