{
  "abstract": "Background\n\nThis study aimed to synthesize evidence on the safety of tuberculosis-preventive treatment (TPT) in children aged <5 years, including those with immunocompromising conditions.Methods\n\nA rapid review was conducted using PubMed, Embase, Virtual Health Library, and the Cochrane Library, including systematic reviews and primary studies.Results\n\nFive studies were included, assessing isoniazid-based regimens. Adverse events were mild and reversible, such as transient liver enzyme elevations and peripheral neuropathy. Severe hepatotoxicity was rare and primarily reported in children with Human Immunodeficiency Virus (HIV).Conclusions\n\nTPT appears generally safe in children aged <5 years; however, evidence remains limited for shorter regimens and immunocompromised populations.",
  "abstract_shown": true,
  "affiliations": [
    "Hcor, São Paulo, SP, Brasil.",
    "Ministério da Saúde, Coordenação-Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias Não Tuberculosas, Brasília, DF, Brasil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liza Yurie Teruya Uchimura",
      "orcid": "0000-0002-4935-2432"
    },
    {
      "affs": [
        0
      ],
      "name": "Tatiana Yonekura",
      "orcid": "0000-0001-8271-6691"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeane Roza Quintans",
      "orcid": "0000-0003-0076-9242"
    },
    {
      "affs": [
        0
      ],
      "name": "Mabel Fernandes Figueiró",
      "orcid": "0000-0003-4195-3732"
    },
    {
      "affs": [
        1
      ],
      "name": "Karina Dos Santos Casado",
      "orcid": "0009-0007-8608-4864"
    },
    {
      "affs": [
        1
      ],
      "name": "Eduardo de Souza Alves",
      "orcid": "0000-0003-2688-2999"
    },
    {
      "affs": [
        1
      ],
      "name": "Fernanda Dockhorn Costa Johansen",
      "orcid": "0000-0002-1762-9484"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniele Maria Pelissari",
      "orcid": "0000-0002-0760-1875"
    },
    {
      "affs": [
        1
      ],
      "name": "Nicole Menezes de Souza",
      "orcid": "0000-0002-9372-7385"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aczeevs06wdsv.bib",
  "cited_by": 0,
  "doi": "10.1590/0037-8682-0029-2026",
  "fulltext_url": "https://europepmc.org/articles/PMC13674191",
  "id": "aczeevs06wdsv",
  "issns": [
    "0037-8682",
    "1678-9849"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912081",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7222622787",
  "pdf_url": "https://europepmc.org/articles/PMC13674191?pdf=render",
  "pmcid": "PMC13674191",
  "pmid": "42912081",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aczeevs06wdsv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912081",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912081"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Tuberculosis Research and Epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Safety of tuberculosis-preventive treatment in children aged under 5 years: A rapid review.",
  "title_text": "Safety of tuberculosis-preventive treatment in children aged under 5 years: A rapid review.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/aczeevs06wdsv",
  "venue": "Revista da Sociedade Brasileira de Medicina Tropical",
  "versions": []
}